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Tyromycic acid

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Tyromycic acid Basic information

Product Name:
Tyromycic acid
Synonyms:
  • Ganoderic acid SZ
  • (Z)-Ganoderic acid S
  • Lanosta-7,9(11),24-trien-26-oic acid, 3-oxo-, (24Z)-
CAS:
865543-37-9
MF:
C30H44O3
MW:
452.67
Mol File:
865543-37-9.mol
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Tyromycic acid Chemical Properties

solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form 
Powder
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Tyromycic acid Usage And Synthesis

Uses

Ganoderic acid SZ is a natural product with 3-hydroxy-3-methylglutaryl-CoA reductase inhibitory activity. Ganoderic acid SZ shows stronger activity than the positive control atorvastatin in inhibiting HMG-CoA reductase. Ganoderic acid SZ exhibits significant inhibition of yeast-derived α-glucosidase with IC50 values achieved at very low concentrations. Ganoderic acid SZ also exhibits cytotoxicity against K562 cells with IC?? values in the range of 10-20 μM[1].

References

[1] Lanostane Triterpenes from the Tibetan Medicinal Mushroom Ganoderma leucocontextum and Their Inhibitory Effects on HMG-CoA Reductase and α-Glucosidase DOI:10.1021/acs.jnatprod.5b00331

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