2-FLUOROPALMITIC ACID Chemical Properties

Boiling point:

376.1±12.0 °C(Predicted)

Density 

0.936±0.06 g/cm3(Predicted)

storage temp. 

−20°C

solubility 

Soluble in DMSO

form 

crystalline solid

pka

2.70±0.21(Predicted)

color 

White to off-white

2-FLUOROPALMITIC ACID Usage And Synthesis

Definition

ChEBI: 2-fluorohexadecanoic acid is a long-chain fatty acid and a fluoro fatty acid.

Biological Activity

2-fluoropalmitic acid inhibits sphingosine biosynthesis and long-chain acyl-coa synthetase [1]. the length of the carbon chain of the fatty acid species defines the substrate specificity for the different acyl-coa synthetases (acs).mammalian long-chain acyl-coa synthetases (acsl) activate fatty acids with chain lengths of 12 to 20 carbon atoms. the long-chain acyl-coa synthetase mrna is expressed virtually in heart, liver, and epididymal adipose tissues and, to a much lesser extent, in brain, small intestine, and lung [2].palmitic acid was a selective cytotoxic substance extracted from the marine algal. at concentrations ranging from 12.5 to 50 μg/ml, palmitic acid showed selective cytotoxicity to human leukemic cells, but no cytotoxicity to normal hdf cells. palmitic acid (50 μg/ml) induced apoptosis in the human leukemic cell line molt-4. palmitic acid also showed in vivo antitumor activity in mice [3]. 2-fluoropalmitic acid showed an inhibitory effect on sphingosine biosynthesis and long-chain acyl-coa synthetase with an ic50 value of 0.2 mm [1].

References

[1] soltysiak r m, matsuura f, bloomer d, et al. d, l-α-fluoropalmitic acid inhibits sphingosine base formation and accumulates in membrane lipids of cultured mammalian cells[j]. biochimica et biophysica acta (bba)-lipids and lipid metabolism, 1984, 792(2): 214-226.
[2] suzuki h, kawarabayasi y, kondo j, et al. structure and regulation of rat long-chain acyl-coa synthetase[j]. journal of biological chemistry, 1990, 265(15): 8681-8685.
[3] harada h, yamashita u, kurihara h, et al. antitumor activity of palmitic acid found as a selective cytotoxic substance in a marine red alga[j]. anticancer research, 2001, 22(5): 2587-2590.

2-FLUOROPALMITIC ACID(16518-94-8)Related Product Information

• FLUOROSULFONIC ACID
• 7-fluoropalmitic acid
• 3-Fluoropalmitic acid
• 2-FLUOROPALMITIC ACID
• 6-fluoropalmitic acid
• 16-fluoropalmitic acid
• 4-Fluoropalmitic acid
• 2-fluoro Palmitic Acid methyl ester
• 2-FLUOROPALMITIC ACID
• METHYL PERFLUOROOCTADECANOATE
• Perfluorooctadecanoic acid
• METHYL PERFLUOROHEXADECANOATE
• 2,2-DIFLUOROPALMITIC ACID
• PERFLUOROHEXADECANOIC ACID