Isophorone oxide Chemical Properties

Boiling point:

75-76 °C/6 mmHg (lit.)

Density 

0.994 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.453(lit.)

Flash point:

182 °F

storage temp. 

Sealed in dry,Room Temperature

form 

clear liquid

color 

Colorless to Light yellow to Light orange

Safety Information

Hazard Codes 

Xn

Risk Statements 

20/21/22-40

Safety Statements 

23-36

RIDADR 

UN 1993 / PGIII

WGK Germany 

3

HS Code 

29142990

MSDS

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Isophorone oxide Usage And Synthesis

Uses

Isophorone oxide could be rearranged to 3,5,5-trimethyl-1,2-cyclohexanedione and 2-formyl-2,4,4-trimethylcyclopentanone with high conversions and selectivities using zeolites and montmorillonite K10 as catalysts.

Synthesis

In a three-necked flask equipped with a dropping funnel, a mechanical stirrer, and a thermometer, a solution of 55.2 g (0.4 mol) of isophorone and 115 ml (1.2 mol) of 30% aqueous hydrogen peroxide in 400 ml of methanol. After the contents of the flask have been cooled to 15 ℃ using an ice bath, 33 ml (0.2 mol) of 6N aqueous sodium hydroxide is added, dropwise and with stirring, over 1 hour. During the addition, the temperature of the reaction mixture is maintained at 15–20℃ with a bath of cold water. After the addition is complete, the resulting mixture is stirred for 3 hours as the reaction mixture temperature is maintained at 20–25℃. The reaction mixture is then poured into 500 ml. of water, and the resulting mixture is extracted with two 400-ml portions of ether. The combined extracts are washed with water and dried over anhydrous magnesium sulfate. After the bulk of the ether has been removed by distillation (or flash distillation) through a 30-cm. Vigreux column at atmospheric pressure, the residual liquid is distilled through the Vigreux column under reduced pressure. The yield of isophorone oxide is 43–44.5 g. (70–72%).

References

[1] J. A. Elings, R. Sheldon, H. Lempers. “Zeolite-catalysed rearrangement of isophorone oxide.” Studies in Surface Science and Catalysis 15 1 (1997): 1165–1172.

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