PentaMidine-d4 2HCl
PentaMidine-d4 2HCl Basic information
- Product Name:
- PentaMidine-d4 2HCl
- Synonyms:
-
- PentaMidine-d4 2HCl
- PentaMidine (dihydrochloride)
- 4,4'-[1,5-Pentanediylbis(oxy)]bisbenzenecarboximidamide] dihydrochloride
- Benzenecarboximidamide, 4,4'-[1,5-pentanediylbis(oxy)]bis-, dihydrochloride (9CI)
- MP601205 dihydrochloride
- MP601205 DIHYDROCHLORIDE;PENTAMIDINE
- PTP1B,Pneumocystis,Parasite,Antibiotic,antitumor,Pentamidine,MP 601205,Inhibitor,Kidney,MP-601205,carinii,Bacterial,cell-cycle,pneumonia,MP601205,Phosphatase,inhibit,DNA,Pentamidine dihydrochloride,biosynthetics,Fungal,arrest
- Pentamidine dihydrochloride, 10 mM in DMSO
- CAS:
- 50357-45-4
- MF:
- C19H26Cl2N4O2
- MW:
- 413.34134
- Product Categories:
-
- Inhibitors
- Mol File:
- 50357-45-4.mol
PentaMidine-d4 2HCl Chemical Properties
- Melting point:
- 232-234°
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO > 10 mM
- form
- Powder
PentaMidine-d4 2HCl Usage And Synthesis
Uses
Pentamidine dihydrochloride (MP-601205 dihydrochloride) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine dihydrochloride inhibits parasite Leishmania infantum with an IC50 of 2.5 μM. Pentamidine dihydrochloride is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine dihydrochloride has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities[1][2][3][4].
Safety Profile
A poison by subcutaneous and intravenous routes. When heated to decomposition it emits toxic vapors of NOx and HCl.
in vivo
Pentamidine (0.25 mg/mouse; intramuscular injection; every 2 days; for 4 weeks; athymic nude mice) treatment markedly inhibits the growth of WM9 human melanoma tumors in nude mice[1].
| Animal Model: | Athymic nude mice (6 weeks old) injected with WM9 cells[1] |
| Dosage: | 0.25 mg/mouse |
| Administration: | Intramuscular injection; every 2 days; for 4 weeks |
| Result: | Markedly inhibited the growth of WM9 human melanoma tumors in nude mice. |
IC 50
Trypanosoma; Leishmania
References
[1] Pathak MK, et al. Pentamidine is an inhibitor of PRL phosphatases with anticancer activity. Mol Cancer Ther. 2002 Dec;1(14):1255-64. PMID:12516958
[2] Nguewa, P.A., et al., Pentamidine is an antiparasitic and apoptotic drug that selectively modifies ubiquitin. Chem Biodivers, 2005. 2(10): p. 1387-400. DOI:10.1002/cbdv.200590111
[3] Sands M, et al. Pentamidine: a review. Rev Infect Dis. 1985 Sep-Oct;7(5):625-34. DOI:10.1093/clinids/7.5.625
[4] David C. Bean, et al. Pentamidine: a drug to consider re-purposing in the targeted treatment of multi-drug resistant bacterial infections? J Lab Precis Med 2017;2:49.
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