PentaMidine-d4 2HCl

Product Name: PentaMidine-d4 2HCl
CAS No.: 50357-45-4
Chemical Name: PentaMidine-d4 2HCl
Synonyms: PentaMidine-d4 2HCl;MP601205 dihydrochloride;PentaMidine (dihydrochloride);MP601205 DIHYDROCHLORIDE;PENTAMIDINE;Pentamidine dihydrochloride, 10 mM in DMSO;4,4'-[1,5-Pentanediylbis(oxy)]bisbenzenecarboximidamide] dihydrochloride;Benzenecarboximidamide, 4,4'-[1,5-pentanediylbis(oxy)]bis-, dihydrochloride (9CI);PTP1B,Pneumocystis,Parasite,Antibiotic,antitumor,Pentamidine,MP 601205,Inhibitor,Kidney,MP-601205,carinii,Bacterial,cell-cycle,pneumonia,MP601205,Phosphatase,inhibit,DNA,Pentamidine dihydrochloride,biosynthetics,Fungal,arrest
CBNumber: CB72646436
Molecular Formula: C19H26Cl2N4O2
Formula Weight: 413.34134
MOL File: 50357-45-4.mol

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PentaMidine-d4 2HCl Property

Melting point:: 232-234°
storage temp.: Store at -20°C
solubility: Soluble in DMSO > 10 mM
form: Powder

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Safety

Toxicity: LD50 in mice (mg/g): 0.028 i.v.; 0.064 s.c. (Wein)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ApexBio Technology

Product number: B3416
Product name: Pentamidinedihydrochloride
Packaging: 50mg
Price: $73
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0307889
Product name: 4,4'-(PENTAMETHYLENEDIOXY)DI-BENZAMIDINE DIHYDROCHLORIDE
Purity: 95.00%
Packaging: 5MG
Price: $500.39
Updated: 2021/12/16

Crysdot

Product number: CD31001733
Product name: Pentamidinedihydrochloride
Purity: 98+%
Packaging: 10mg
Price: $46
Updated: 2021/12/16

Crysdot

Product number: CD31001733
Product name: Pentamidinedihydrochloride
Purity: 98+%
Packaging: 50mg
Price: $137
Updated: 2021/12/16

Crysdot

Product number: CD31001733
Product name: Pentamidinedihydrochloride
Purity: 98+%
Packaging: 100mg
Price: $208
Updated: 2021/12/16

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PentaMidine-d4 2HCl Chemical Properties,Usage,Production

Uses

Pentamidine dihydrochloride (MP-601205 dihydrochloride) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine dihydrochloride inhibits parasite Leishmania infantum with an IC50 of 2.5 μM. Pentamidine dihydrochloride is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine dihydrochloride has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities[1][2][3][4].

Safety Profile

A poison by subcutaneous and intravenous routes. When heated to decomposition it emits toxic vapors of NOx and HCl.

in vivo

Pentamidine (0.25 mg/mouse; intramuscular injection; every 2 days; for 4 weeks; athymic nude mice) treatment markedly inhibits the growth of WM9 human melanoma tumors in nude mice^[1].

Animal Model:	Athymic nude mice (6 weeks old) injected with WM9 cells^[1]
Dosage:	0.25 mg/mouse
Administration:	Intramuscular injection; every 2 days; for 4 weeks
Result:	Markedly inhibited the growth of WM9 human melanoma tumors in nude mice.

IC 50

Trypanosoma; Leishmania

References

[1] Pathak MK, et al. Pentamidine is an inhibitor of PRL phosphatases with anticancer activity. Mol Cancer Ther. 2002 Dec;1(14):1255-64. PMID:12516958
[2] Nguewa, P.A., et al., Pentamidine is an antiparasitic and apoptotic drug that selectively modifies ubiquitin. Chem Biodivers, 2005. 2(10): p. 1387-400. DOI:10.1002/cbdv.200590111
[3] Sands M, et al. Pentamidine: a review. Rev Infect Dis. 1985 Sep-Oct;7(5):625-34. DOI:10.1093/clinids/7.5.625
[4] David C. Bean, et al. Pentamidine: a drug to consider re-purposing in the targeted treatment of multi-drug resistant bacterial infections? J Lab Precis Med 2017;2:49.

PentaMidine-d4 2HCl Preparation Products And Raw materials

Raw materials

Preparation Products

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PentaMidine-d4 2HCl Suppliers

China 25 India 1 United States 7 Global 33

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
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Clearsynth Labs Limited

Tel: +91-22-26355700
Fax: +91-22-26355701
Email: info@clearsynth.com
Country: India
ProdList: 9679
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Hubei Jusheng Technology Co.,Ltd

Tel: 027-59599241 18871490274
Fax: 027-59599241
Email: 1400878000@qq.com
Country: China
ProdList: 9858
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Shanghai Changyan Chem & Tech Co., Ltd.

Tel: 021-20242659 18930833303
Fax: +86 (21) 2024-2659
Email: Sales@changyanchem.cn
Country: China
ProdList: 5001
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Target molecule Corp.

Tel: 857-239-0968
Fax: 857-239-8801
Email: service1@targetmol.com
Country: United States
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Amadis Chemical Company Limited

Tel: 571-89925085
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Country: China
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Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12306
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Chuzhou KeMail Chemical Technology Co., Ltd

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Email: wj520wjxby@126.com
Country: China
ProdList: 1944
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Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
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Country: United States
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Angel Pharmatech, Ltd.

Tel: 17317130613
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Email: 3358272972@qq.com
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PentaMidine-d4 2HCl

PentaMidine (dihydrochloride)

4,4'-[1,5-Pentanediylbis(oxy)]bisbenzenecarboximidamide] dihydrochloride

Benzenecarboximidamide, 4,4'-[1,5-pentanediylbis(oxy)]bis-, dihydrochloride (9CI)

MP601205 dihydrochloride

MP601205 DIHYDROCHLORIDE;PENTAMIDINE

PTP1B,Pneumocystis,Parasite,Antibiotic,antitumor,Pentamidine,MP 601205,Inhibitor,Kidney,MP-601205,carinii,Bacterial,cell-cycle,pneumonia,MP601205,Phosphatase,inhibit,DNA,Pentamidine dihydrochloride,biosynthetics,Fungal,arrest

Pentamidine dihydrochloride, 10 mM in DMSO

50357-45-4

C19H24N4O22HCl

C19H26Cl2N4O2

Inhibitors