VUF 5574 Chemical Properties

Melting point:

257-258 °C

Boiling point:

444.8±45.0 °C(Predicted)

Density 

1.360±0.06 g/cm3(Predicted)

storage temp. 

Store at RT

solubility 

DMSO: 1.5 mg/mL, soluble

form 

solid

pka

-2.06±0.43(Predicted)

color 

white

Safety Information

Safety Statements 

22-24/25

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

VUF 5574 Usage And Synthesis

Description

VUF 5574 is an antagonist of the adenosine A₃ receptor (K_i = 4.03 nM for the recombinant human receptor). It is greater than 2,500-fold selective for adenosine A₃ over A₁ and A_2A receptors. VUF 5574 (100 nM) decreases phosphorylation of ERK1/2 induced by adenosine in isolated porcine coronary artery smooth muscle cells. It increases oxygen-glucose deprivation-induced reductions in the amplitude of field excitatory postsynaptic potentials (EPSPs) in a rat hippocampal slice model of ischemia when used at a concentration of 100 nM. VUF 5574 (2 μg, intracisternal) reduces sodium nitroprusside-induced heart rate increases in rats.

Uses

VUF 5574 is an adenosine A3 receptor antagonist.

Biological Activity

Potent, selective, competitive antagonist for the human adenosine A 3 receptor (K i = 4 nM). Displays ≥ 2500-fold selectivity over A 1 and A 2A receptors.

VUF 5574(280570-45-8)Related Product Information

• 2-PYRIDIN-3-YL-QUINAZOLIN-4-YLAMINE
• VUF 5574