ChemicalBook > CAS DataBase List > VUF 5574

VUF 5574

Product Name
VUF 5574
CAS No.
280570-45-8
Chemical Name
VUF 5574
Synonyms
VUF 5574;3-(2-methoxyphenyl)-1-(2-pyridin-3-ylquinazolin-4-yl)urea;N-(2-METHOXYPHENYL)-N-[2-(3-PYRIDINYL)-4-QUINAZOLINYL]-UREA;1-(2-Methoxy-phenyl)-3-(2-pyridin-3-yl-quinazolin-4-yl)-urea;N-(2-METHOXYPHENYL)-N'-[2-(3-PYRINDINYL)-4-QUINAZOLINYL]-UREA;Urea, N-(2-methoxyphenyl)-N'-[2-(3-pyridinyl)-4-quinazolinyl]-
CBNumber
CB7267332
Molecular Formula
C21H17N5O2
Formula Weight
371.39
MOL File
280570-45-8.mol
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VUF 5574 Property

Melting point:
257-258 °C
Boiling point:
444.8±45.0 °C(Predicted)
Density 
1.360±0.06 g/cm3(Predicted)
storage temp. 
Store at RT
solubility 
DMSO: 1.5 mg/mL, soluble
form 
solid
pka
-2.06±0.43(Predicted)
color 
white
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
27676
Product name
VUF 5574
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
27676
Product name
VUF 5574
Packaging
5mg
Price
$116
Updated
2024/03/01
Cayman Chemical
Product number
27676
Product name
VUF 5574
Packaging
10mg
Price
$153
Updated
2024/03/01
Tocris
Product number
1359
Product name
VUF5574
Purity
≥98%(HPLC)
Packaging
10
Price
$132
Updated
2021/12/16
Tocris
Product number
1359
Product name
VUF5574
Purity
≥98%(HPLC)
Packaging
50
Price
$540
Updated
2021/12/16
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VUF 5574 Chemical Properties,Usage,Production

Description

VUF 5574 is an antagonist of the adenosine A3 receptor (Ki = 4.03 nM for the recombinant human receptor). It is greater than 2,500-fold selective for adenosine A3 over A1 and A2A receptors. VUF 5574 (100 nM) decreases phosphorylation of ERK1/2 induced by adenosine in isolated porcine coronary artery smooth muscle cells. It increases oxygen-glucose deprivation-induced reductions in the amplitude of field excitatory postsynaptic potentials (EPSPs) in a rat hippocampal slice model of ischemia when used at a concentration of 100 nM. VUF 5574 (2 μg, intracisternal) reduces sodium nitroprusside-induced heart rate increases in rats.

Uses

VUF 5574 is an adenosine A3 receptor antagonist.

Biological Activity

Potent, selective, competitive antagonist for the human adenosine A 3 receptor (K i = 4 nM). Displays ≥ 2500-fold selectivity over A 1 and A 2A receptors.

IC 50

Recombinant Human Adenosine A3 receptor (A3R): 4.03 nM (Ki)

References

[1] JACQUELINE E. VAN MUIJLWIJK-KOEZEN. Isoquinoline and Quinazoline Urea Analogues as Antagonists for the Human Adenosine A3 Receptor[J]. Journal of Medicinal Chemistry, 2000, 43 11: 2227-2238. DOI: 10.1021/jm000002u
[2] JIANZHONG SHEN. Cell-signaling evidence for adenosine stimulation of coronary smooth muscle proliferation via the A1 adenosine receptor.[J]. Circulation research, 2005, 97 6: 574-582. DOI: 10.1161/01.res.0000181159.83588.4b
[3] ANNA MARIA PUGLIESE. A3 adenosine receptor antagonists delay irreversible synaptic failure caused by oxygen and glucose deprivation in the rat CA1 hippocampus in vitro[J]. British Journal of Pharmacology, 2009, 147 5: 524-532. DOI: 10.1038/sj.bjp.0706646
[4] MAHMOUD M. EL-MAS. Role of adenosine A2A receptor signaling in the nicotine-evoked attenuation of reflex cardiac sympathetic control[J]. Toxicology and applied pharmacology, 2011, 254 3: Pages 229-237. DOI: 10.1016/j.taap.2011.04.014

VUF 5574 Preparation Products And Raw materials

Raw materials

Preparation Products

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VUF 5574 Suppliers

China 39 Germany 3 Switzerland 1 United Kingdom 1 United States 7 Global 51
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15838
Advantage
69
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
15883
Advantage
64
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4720
Advantage
55
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
42446
Advantage
60
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9119
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
ShangHai ChuanQian Chemcial Technique Centre
Tel
15869524721
Email
3525679403@qq.com
Country
China
ProdList
4989
Advantage
58

280570-45-8, VUF 5574Related Search:

2-PYRIDIN-3-YL-QUINAZOLIN-4-YLAMINE VUF 5574

  • VUF 5574
  • N-(2-METHOXYPHENYL)-N-[2-(3-PYRIDINYL)-4-QUINAZOLINYL]-UREA
  • N-(2-METHOXYPHENYL)-N'-[2-(3-PYRINDINYL)-4-QUINAZOLINYL]-UREA
  • 1-(2-Methoxy-phenyl)-3-(2-pyridin-3-yl-quinazolin-4-yl)-urea
  • Urea, N-(2-methoxyphenyl)-N'-[2-(3-pyridinyl)-4-quinazolinyl]-
  • 3-(2-methoxyphenyl)-1-(2-pyridin-3-ylquinazolin-4-yl)urea
  • 280570-45-8
  • Adenosine receptor