ChemicalBook > CAS DataBase List > VUF 5574

VUF 5574

Product Name
VUF 5574
CAS No.
280570-45-8
Chemical Name
VUF 5574
Synonyms
VUF 5574;N-(2-METHOXYPHENYL)-N-[2-(3-PYRIDINYL)-4-QUINAZOLINYL]-UREA;1-(2-Methoxy-phenyl)-3-(2-pyridin-3-yl-quinazolin-4-yl)-urea;N-(2-METHOXYPHENYL)-N'-[2-(3-PYRINDINYL)-4-QUINAZOLINYL]-UREA;Urea, N-(2-methoxyphenyl)-N'-[2-(3-pyridinyl)-4-quinazolinyl]-
CBNumber
CB7267332
Molecular Formula
C21H17N5O2
Formula Weight
371.39
MOL File
280570-45-8.mol
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VUF 5574 Property

Melting point:
257-258 °C
Boiling point:
444.8±45.0 °C(Predicted)
Density 
1.360±0.06 g/cm3(Predicted)
storage temp. 
Store at RT
solubility 
DMSO: 1.5 mg/mL, soluble
form 
solid
pka
-2.06±0.43(Predicted)
color 
white
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
27676
Product name
VUF 5574
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
27676
Product name
VUF 5574
Packaging
5mg
Price
$116
Updated
2024/03/01
Cayman Chemical
Product number
27676
Product name
VUF 5574
Packaging
10mg
Price
$153
Updated
2024/03/01
Tocris
Product number
1359
Product name
VUF5574
Purity
≥98%(HPLC)
Packaging
10
Price
$132
Updated
2021/12/16
Tocris
Product number
1359
Product name
VUF5574
Purity
≥98%(HPLC)
Packaging
50
Price
$540
Updated
2021/12/16
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VUF 5574 Chemical Properties,Usage,Production

Description

VUF 5574 is an antagonist of the adenosine A3 receptor (Ki = 4.03 nM for the recombinant human receptor). It is greater than 2,500-fold selective for adenosine A3 over A1 and A2A receptors. VUF 5574 (100 nM) decreases phosphorylation of ERK1/2 induced by adenosine in isolated porcine coronary artery smooth muscle cells. It increases oxygen-glucose deprivation-induced reductions in the amplitude of field excitatory postsynaptic potentials (EPSPs) in a rat hippocampal slice model of ischemia when used at a concentration of 100 nM. VUF 5574 (2 μg, intracisternal) reduces sodium nitroprusside-induced heart rate increases in rats.

Uses

VUF 5574 is an adenosine A3 receptor antagonist.

Biological Activity

Potent, selective, competitive antagonist for the human adenosine A 3 receptor (K i = 4 nM). Displays ≥ 2500-fold selectivity over A 1 and A 2A receptors.

VUF 5574 Preparation Products And Raw materials

Raw materials

Preparation Products

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VUF 5574 Suppliers

China 32 Germany 3 Switzerland 1 United Kingdom 1 United States 8 Global 45
SIGMA-RBI
Tel
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Fax
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Country
Switzerland
ProdList
6896
Advantage
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280570-45-8, VUF 5574Related Search:

2-PYRIDIN-3-YL-QUINAZOLIN-4-YLAMINE VUF 5574

  • VUF 5574
  • N-(2-METHOXYPHENYL)-N-[2-(3-PYRIDINYL)-4-QUINAZOLINYL]-UREA
  • N-(2-METHOXYPHENYL)-N'-[2-(3-PYRINDINYL)-4-QUINAZOLINYL]-UREA
  • 1-(2-Methoxy-phenyl)-3-(2-pyridin-3-yl-quinazolin-4-yl)-urea
  • Urea, N-(2-methoxyphenyl)-N'-[2-(3-pyridinyl)-4-quinazolinyl]-
  • 280570-45-8
  • Adenosine receptor