ChemicalBook > CAS DataBase List > VUF 5574

VUF 5574

Product Name
VUF 5574
CAS No.
280570-45-8
Chemical Name
VUF 5574
Synonyms
VUF 5574;N-(2-METHOXYPHENYL)-N-[2-(3-PYRIDINYL)-4-QUINAZOLINYL]-UREA;1-(2-Methoxy-phenyl)-3-(2-pyridin-3-yl-quinazolin-4-yl)-urea;N-(2-METHOXYPHENYL)-N'-[2-(3-PYRINDINYL)-4-QUINAZOLINYL]-UREA;Urea, N-(2-methoxyphenyl)-N'-[2-(3-pyridinyl)-4-quinazolinyl]-
CBNumber
CB7267332
Molecular Formula
C21H17N5O2
Formula Weight
371.39
MOL File
280570-45-8.mol
More
Less

VUF 5574 Property

Melting point:
257-258 °C
Boiling point:
444.8±45.0 °C(Predicted)
Density 
1.360±0.06 g/cm3(Predicted)
storage temp. 
Store at RT
solubility 
DMSO: 1.5 mg/mL, soluble
form 
solid
pka
-2.06±0.43(Predicted)
color 
white
More
Less

Safety

Safety Statements 
22-24/25
WGK Germany 
3
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
27676
Product name
VUF 5574
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
27676
Product name
VUF 5574
Packaging
5mg
Price
$116
Updated
2024/03/01
Cayman Chemical
Product number
27676
Product name
VUF 5574
Packaging
10mg
Price
$153
Updated
2024/03/01
Tocris
Product number
1359
Product name
VUF5574
Purity
≥98%(HPLC)
Packaging
10
Price
$132
Updated
2021/12/16
Tocris
Product number
1359
Product name
VUF5574
Purity
≥98%(HPLC)
Packaging
50
Price
$540
Updated
2021/12/16
More
Less

VUF 5574 Chemical Properties,Usage,Production

Description

VUF 5574 is an antagonist of the adenosine A3 receptor (Ki = 4.03 nM for the recombinant human receptor). It is greater than 2,500-fold selective for adenosine A3 over A1 and A2A receptors. VUF 5574 (100 nM) decreases phosphorylation of ERK1/2 induced by adenosine in isolated porcine coronary artery smooth muscle cells. It increases oxygen-glucose deprivation-induced reductions in the amplitude of field excitatory postsynaptic potentials (EPSPs) in a rat hippocampal slice model of ischemia when used at a concentration of 100 nM. VUF 5574 (2 μg, intracisternal) reduces sodium nitroprusside-induced heart rate increases in rats.

Uses

VUF 5574 is an adenosine A3 receptor antagonist.

Biological Activity

Potent, selective, competitive antagonist for the human adenosine A 3 receptor (K i = 4 nM). Displays ≥ 2500-fold selectivity over A 1 and A 2A receptors.

VUF 5574 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

VUF 5574 Suppliers

China 32 Germany 3 Switzerland 1 United Kingdom 1 United States 8 Global 45
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
19185
Advantage
64
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4674
Advantage
55
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
7323
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
ShangHai ChuanQian Chemcial Technique Centre
Tel
15869524721
Email
3525679403@qq.com
Country
China
ProdList
4345
Advantage
58
Changzhou Furuisi Biotechnology Co., Ltd
Tel
0519-85524369
Email
3477467573@qq.com
Country
China
ProdList
8617
Advantage
58
Jinan Jiuli Biotechnology Co. , Ltd.
Tel
15865264761
Email
486064515@qq.com
Country
China
ProdList
4992
Advantage
58
Hubei Kele Fine Chemical Co., Ltd
Tel
027-59101668 19945030958
Fax
027-59101668
Email
2881924765@qq.com
Country
China
ProdList
7958
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24644
Advantage
58
Xianning Shen Lan Biomedical Research and Development Co., Ltd.
Tel
18171815831
Email
1341138380@qq.com
Country
China
ProdList
3769
Advantage
58
Suzhou Daolan Biomedical Technology Co., Ltd.
Tel
13771737464
Email
sales@dolanchem.com
Country
China
ProdList
2351
Advantage
58
Shanghai Aladdin Biochemical Technology Co.,Ltd.
Tel
400-6206333 18021050169
Email
market@aladdin-e.com
Country
China
ProdList
48460
Advantage
58
Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd.
Tel
025-66061636 18013972705
Email
qqyang@aikonchem.com
Country
China
ProdList
10238
Advantage
58
Shandong Dongde New Materials Co., Ltd
Tel
13290191024
Email
3887351301@qq.com
Country
China
ProdList
875
Advantage
58
Sangon Biotech (Shanghai) Co.,Ltd.
Tel
400-821-026
Email
sangon@qq.com
Country
China
ProdList
47240
Advantage
58
LEAPCHEM CO., LTD.
Tel
+86-852-30606658
Email
market18@leapchem.com
Country
China
ProdList
43340
Advantage
58
Wuhan Topule Biopharmaceutical Co., Ltd
Tel
+8618327326525
Email
masar@topule.com
Country
China
ProdList
8467
Advantage
58
Neobioscience Co., Ltd.
Tel
--
Fax
--
Email
info@neobioscience.com
Country
CHINA
ProdList
6207
Advantage
58
Absin Bioscience Inc.
Tel
--
Fax
--
Email
chenjw@absin.cn
Country
CHINA
ProdList
6743
Advantage
58
Proteintech China
Tel
--
Fax
--
Email
Proteintech-CN@ptglab.com
Country
CHINA
ProdList
6290
Advantage
58
Beijing Taize Jiaye Technology Development Co., Ltd.
Tel
--
Fax
--
Country
CHINA
ProdList
6050
Advantage
58
Wuxi Laifusi Biological Experimental Equipment Co., Ltd.
Tel
--
Fax
--
Email
marketing@lifesbiology.com
Country
CHINA
ProdList
668
Advantage
58
Shanghai Chaoyan Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
471161314@qq.com
Country
CHINA
ProdList
6210
Advantage
58
Xiamen Huijia Biological Technology Co., Ltd.
Tel
--
Fax
--
Country
CHINA
ProdList
6973
Advantage
58
Beijing Fubo Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
info@f-biology.com
Country
CHINA
ProdList
6025
Advantage
58
Qingdao Jieshikang Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
jskangchina@163.com
Country
CHINA
ProdList
4012
Advantage
58
Beijing Bolide Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
1985563437@qq.com
Country
CHINA
ProdList
6158
Advantage
58
Shanghai Weiwei Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
sales@wheybio.com
Country
CHINA
ProdList
4398
Advantage
58
Beijing Taize Ruida Technology Co., Ltd.
Tel
--
Fax
--
Email
taizeorder@163.com
Country
CHINA
ProdList
6536
Advantage
58
Shanghai Yuda Industrial Co., Ltd.
Tel
--
Fax
--
Email
lucy@runwelltac.com
Country
CHINA
ProdList
6105
Advantage
58
Shanghai Haoyang Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
596799915@QQ.COM
Country
CHINA
ProdList
2905
Advantage
58

280570-45-8, VUF 5574Related Search:

2-PYRIDIN-3-YL-QUINAZOLIN-4-YLAMINE VUF 5574

  • VUF 5574
  • N-(2-METHOXYPHENYL)-N-[2-(3-PYRIDINYL)-4-QUINAZOLINYL]-UREA
  • N-(2-METHOXYPHENYL)-N'-[2-(3-PYRINDINYL)-4-QUINAZOLINYL]-UREA
  • 1-(2-Methoxy-phenyl)-3-(2-pyridin-3-yl-quinazolin-4-yl)-urea
  • Urea, N-(2-methoxyphenyl)-N'-[2-(3-pyridinyl)-4-quinazolinyl]-
  • 280570-45-8
  • Adenosine receptor