VUF 5574

Product Name: VUF 5574
CAS No.: 280570-45-8
Chemical Name: VUF 5574
Synonyms: VUF 5574;N-(2-METHOXYPHENYL)-N-[2-(3-PYRIDINYL)-4-QUINAZOLINYL]-UREA;1-(2-Methoxy-phenyl)-3-(2-pyridin-3-yl-quinazolin-4-yl)-urea;N-(2-METHOXYPHENYL)-N'-[2-(3-PYRINDINYL)-4-QUINAZOLINYL]-UREA;Urea, N-(2-methoxyphenyl)-N'-[2-(3-pyridinyl)-4-quinazolinyl]-
CBNumber: CB7267332
Molecular Formula: C21H17N5O2
Formula Weight: 371.39
MOL File: 280570-45-8.mol

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VUF 5574 Property

Melting point:: 257-258 °C
Boiling point:: 444.8±45.0 °C(Predicted)
Density: 1.360±0.06 g/cm3(Predicted)
storage temp.: Store at RT
solubility: DMSO: 1.5 mg/mL, soluble
form: solid
pka: -2.06±0.43(Predicted)
color: white

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Safety

Safety Statements: 22-24/25
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 27676
Product name: VUF 5574
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 27676
Product name: VUF 5574
Packaging: 5mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 27676
Product name: VUF 5574
Packaging: 10mg
Price: $153
Updated: 2024/03/01

Tocris

Product number: 1359
Product name: VUF5574
Purity: ≥98%(HPLC)
Packaging: 10
Price: $132
Updated: 2021/12/16

Tocris

Product number: 1359
Product name: VUF5574
Purity: ≥98%(HPLC)
Packaging: 50
Price: $540
Updated: 2021/12/16

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VUF 5574 Chemical Properties,Usage,Production

Description

VUF 5574 is an antagonist of the adenosine A₃ receptor (K_i = 4.03 nM for the recombinant human receptor). It is greater than 2,500-fold selective for adenosine A₃ over A₁ and A_2A receptors. VUF 5574 (100 nM) decreases phosphorylation of ERK1/2 induced by adenosine in isolated porcine coronary artery smooth muscle cells. It increases oxygen-glucose deprivation-induced reductions in the amplitude of field excitatory postsynaptic potentials (EPSPs) in a rat hippocampal slice model of ischemia when used at a concentration of 100 nM. VUF 5574 (2 μg, intracisternal) reduces sodium nitroprusside-induced heart rate increases in rats.

Uses

VUF 5574 is an adenosine A3 receptor antagonist.

Biological Activity

Potent, selective, competitive antagonist for the human adenosine A 3 receptor (K i = 4 nM). Displays ≥ 2500-fold selectivity over A 1 and A 2A receptors.

VUF 5574 Preparation Products And Raw materials

Raw materials

Preparation Products

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VUF 5574 Suppliers

China 32 Germany 3 Switzerland 1 United Kingdom 1 United States 8 Global 45

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
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Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 19185
Advantage: 64

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 14055
Advantage: 65

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4674
Advantage: 55

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8447
Advantage: 60

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 7323
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

ShangHai ChuanQian Chemcial Technique Centre

Tel: 15869524721
Email: 3525679403@qq.com
Country: China
ProdList: 4345
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Changzhou Furuisi Biotechnology Co., Ltd

Tel: 0519-85524369
Email: 3477467573@qq.com
Country: China
ProdList: 8617
Advantage: 58

280570-45-8, VUF 5574Related Search:

2-PYRIDIN-3-YL-QUINAZOLIN-4-YLAMINE VUF 5574

VUF 5574

N-(2-METHOXYPHENYL)-N-[2-(3-PYRIDINYL)-4-QUINAZOLINYL]-UREA

N-(2-METHOXYPHENYL)-N'-[2-(3-PYRINDINYL)-4-QUINAZOLINYL]-UREA

1-(2-Methoxy-phenyl)-3-(2-pyridin-3-yl-quinazolin-4-yl)-urea

Urea, N-(2-methoxyphenyl)-N'-[2-(3-pyridinyl)-4-quinazolinyl]-

280570-45-8

Adenosine receptor