EMpagliflozin-d4 Chemical Properties

Boiling point:

664.458±55.00 °C(Press: 760.00 Torr)(predicted)

Density 

1.399±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)

solubility 

DMSO: Solube

pka

13.233±0.70(predicted)

form 

Solid

color 

White to off-white

EMpagliflozin-d4 Usage And Synthesis

Uses

Empagliflozin-d4 is deuterium labeled Empagliflozin. Empagliflozin (BI 107730 is a selective sodium glucose cotransporter-2 (SGLT-2) inhibitor with an IC50 of 3.1 nM for human SGLT-2[1].

References

[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Grempler R, et al. Empagliflozin, a novel selective sodium glucose cotransporter-2 (SGLT-2) inhibitor: characterisation and comparison with other SGLT-2 inhibitors. Diabetes Obes Metab. 2012 Jan;14(1):83-90. DOI:10.1111/j.1463-1326.2011.01517.x
[3] Cheng ST, et al. The Effects of Empagliflozin, an SGLT2 Inhibitor, on Pancreatic β-Cell Mass and Glucose Homeostasis in Type 1 Diabetes. PLoS One. 2016 Jan 25;11(1):e0147391. DOI:10.1371/journal.pone.0147391
[4] Nikole J.ByrneBSc, et al. Empagliflozin Prevents Worsening of Cardiac Function in an Experimental Model of Pressure Overload-Induced Heart Failure. JACC Basic Transl Sci. 2017 Aug;2(4):347-354.
[5] Sakaeda T, et al. Susceptibility to serious skin and subcutaneous tissue disorders and skin tissue distribution of sodium-dependent glucose co-transporter type 2 (SGLT2) inhibitors. Int J Med Sci. 2018 Jun 13;15(9):937-943. DOI:10.7150/ijms.22224
[6] BOWEN LIN. Glycemic control with empagliflozin, a novel selective SGLT2 inhibitor, ameliorates cardiovascular injury and cognitive dysfunction in obese and type 2 diabetic mice.[J]. Cardiovascular Diabetology, 2014: 148. DOI: 10.1186/s12933-014-0148-1