Basic information Safety Supplier Related
ChemicalBook >  Product Catalog >  Biochemical Engineering >  Biochemical Reagents >  Agonist Inhibitors >  GSK2141795 (hydrochloride)

GSK2141795 (hydrochloride)

Basic information Safety Supplier Related

GSK2141795 (hydrochloride) Basic information

Product Name:
GSK2141795 (hydrochloride)
Synonyms:
  • GSK2141795 (hydrochloride)
  • Uprosertib HCl salt , GSK2141795C HCl salt
  • GSK2141795 HCl
  • N-[(2S)-1-amino-3-(3,4-difluorophenyl)propan-2-yl]-5-chloro-4-(4-chloro-2-methylpyrazol-3-yl)furan-2-carboxamide
  • CS-1303
  • Uprosertib hydrochloride
  • Uprosertib (GSK2141795) HCl
CAS:
1047635-80-2
MF:
C18H17Cl3F2N4O2
MW:
465.71
Mol File:
1047635-80-2.mol
More
Less

GSK2141795 (hydrochloride) Chemical Properties

storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Powder
More
Less

GSK2141795 (hydrochloride) Usage And Synthesis

Uses

Uprosertib hydrochloride (GSK2141795 hydrochloride) is a potent and selective pan-Akt inhibitor with IC50 values of 180/328/38 nM for Akt1/Akt2/Akt3, respectively.

IC 50

Akt3: 38 nM (IC50); Akt1: 180 nM (IC50); Akt2: 328 nM (IC50); ROCK1: 1570 nM (IC50); ROCK2: 1850 nM (IC50); CDK7: 2100 nM (IC50)

References

[1] Pachl F, et al. Characterization of a chemical affinity probe targeting Akt kinases. J Proteome Res. 2013 Aug 2;12(8):3792-800. DOI:10.1021/pr400455j

GSK2141795 (hydrochloride)Supplier

LETOPHARM LIMITED
Tel
+86-21-5821 5861
Email
sales@letopharm.com
Shanghai YuanQi Biotechnology Co., Ltd.
Tel
+86-2332782371 +86-18120098618
Email
sales@adobechem.com
SPIRO PHARMA
Tel
Email
eric_feng1954@126.com
Amadis Chemical Company Limited
Tel
571-89925085
Email
sales@amadischem.com
Musechem
Tel
+1-800-259-7612
Email
info@musechem.com