Z-Ile-Glu-Pro-Phe-OMe
Z-Ile-Glu-Pro-Phe-OMe Basic information
- Product Name:
- Z-Ile-Glu-Pro-Phe-OMe
- Synonyms:
-
- Z-Ile-Glu-Pro-Phe-OMe
- CH-5450 (Z-Ile-Glu-Pro-Phe-CO2Me)
- CH 5450
- Z-ILE-GLU-PRO-PHE-CO2ME
- Z-Ile-Glu-Pro-Phe-Ome, BR
- L-Phenylalanine, N-[(phenylmethoxy)carbonyl]-L-isoleucyl-L-α-glutamyl-L-prolyl-, 4-methyl ester
- CH5450,inhibit,MAB elastase 2,CH 5450,Inhibitor,Ang I,chymase,CH-5450
- CAS:
- 252557-97-4
- MF:
- C34H44N4O9
- MW:
- 652.75
- Mol File:
- 252557-97-4.mol
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Z-Ile-Glu-Pro-Phe-OMe Chemical Properties
- Boiling point:
- 928.4±65.0 °C(Predicted)
- Density
- 1.251±0.06 g/cm3(Predicted)
- pka
- 4.48±0.10(Predicted)
- form
- Solid
- color
- White to off-white
- Sequence
- Z-Ile-Glu-Pro-Phe-OMe
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Z-Ile-Glu-Pro-Phe-OMe Usage And Synthesis
Uses
CH 5450 (Z-Ile-Glu-Pro-Phe-Ome) is a selective short peptide human cardiac chymase inhibitor. CH-5450 inhibits the action of rat MAB elastase 2 on substrate Ang I with an IC50 value of 49 μM and N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide with an IC50 value of 4.8 μM[1].
References
[1] Carlos F Santos, et al. Kinetic characterization and inhibition of the rat MAB elastase-2, an angiotensin I-converting serine protease. Can J Physiol Pharmacol. 2002 Jan;80(1):42-7. DOI:10.1139/y02-004
Z-Ile-Glu-Pro-Phe-OMeSupplier
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