ChemicalBook > Product Catalog > Biochemical Engineering > Biochemical Reagents > Agonist Inhibitors > HUHS015
HUHS015
HUHS015 Basic information
- Product Name:
- HUHS015
- Synonyms:
-
- HUHS015
- 4-Benzyl-3-methyl-1-(6-methyl-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-5-ol
- HUHS-015;HUHS 015
- 1H-Pyrazol-5-ol, 3-methyl-1-(6-methyl-1H-benzimidazol-2-yl)-4-(phenylmethyl)-
- prostate,ALKBH3,antigen-1,HUHS015,HUHS 015,PCA-1,inhibit,HUHS-015,Inhibitor,cancer
- HUHS015, 10 mM in DMSO
- CAS:
- 1453097-13-6
- MF:
- C19H18N4O
- MW:
- 318.37
- Mol File:
- 1453097-13-6.mol
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HUHS015 Chemical Properties
- Boiling point:
- 585.2±42.0 °C(Predicted)
- Density
- 1.30±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:34.0(Max Conc. mg/mL);106.79(Max Conc. mM)
- form
- A crystalline solid
- pka
- 8.12±0.50(Predicted)
- color
- White to off-white
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HUHS015 Usage And Synthesis
Uses
HUHS 015 is used in preparation of arylpyrazolol derivatives as antigen-1 (PCA-1/ALKBH3) inhibitors for anti-prostate cancer drugs.
in vivo
HUHS015 potently suppresses the growth of DU145 cells in a mouse xenograft model[1].
HUHS015 displays 7.2% bioavailability (BA) in rats after oral administration[1].
| Animal Model: | Nude mice[1] |
| Dosage: | 32 mg/kg |
| Administration: | Subcutaneous injection; daily; 6 days |
| Result: | Has inhibitory effect on the growth of subcutaneously implanted DU145, without limiting weight gains after a 6 days continuous administration. |
HUHS015Supplier
Shanghai Boyle Chemical Co., Ltd.
- Tel
- sales@boylechem.com
Shanghai Lollane Biological Technology Co.,Ltd.
- Tel
- 021-52996696，15000506266 15000506266
Wuhan Greatwall chemical Co,.LTD
- Tel
- 400-027-6116 18086000087
- sales@chemgreatwall.com
ShangHai Biochempartner Co.,Ltd
- Tel
- 177-54423994 17754423994
- 2853530910@QQ.com
Beijing Solarbio Science & Tecnology Co., Ltd.
- Tel
- 010-50973130 18101056239
- 3193328036@qq.com