N-Succinimidyl-N-methylcarbamate Chemical Properties

Melting point:

148-153 °C

Density 

1.41±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

Dichloromethane (Slightly), DMSO (Slightly)

pka

11.00±0.46(Predicted)

form 

Solid

color 

White to Off-White

Water Solubility 

Slightly soluble in water.

Sensitive 

Moisture Sensitive

BRN 

1531863

CAS DataBase Reference

18342-66-0(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

F 

10-21

HS Code 

2928.00.5000

MSDS

• Language:English Provider:SigmaAldrich

N-Succinimidyl-N-methylcarbamate Usage And Synthesis

Uses

N-Succinimidyl N-Methylcarbamate is used as a reagent in the synthesis of Argifin, a natural product chitinase inhibitor with chemotherapeutic potential. N-Succinimidyl N-Methylcarbamate is also used as a reagent in the preparation of 5-Amino-N1-methyl-1H-imidazole-1,4-dicarboxamide (A616300); a metabolite of Temozolomide (T017775) which is an imidazotetrazine alkylating agent and antineoplastic.

Definition

ChEBI: N-succinimidyl N-methylcarbamate is a member of the class of pyrrolidinones that is N-hydroxysuccinimide in which the hydroxyl hydrogen is replaced by a methylcarbamoyl group. It has a role as an apoptosis inducer. It is a carbamate ester, a dicarboximide, a pyrrolidinone and a N-hydroxysuccinimide ester. It is functionally related to a succinimide.

N-Succinimidyl-N-methylcarbamate(18342-66-0)Related Product Information

• POLYURETHANE
• Methyl anthranilate
• Urethane
• Dithiooxamide
• 4-Aminobenzoic acid
• 6-Aminoquinolyl-N-hydroxysuccinimidylcarbamate
• Anthranilic acid
• TERT-BUTYL N-SUCCINIMIDYL N,N'-TRIMETHYLENEDICARBAMATE
• TERT-BUTYL N-SUCCINIMIDYL N,N'-(1,4-PHENYLENE)DICARBAMATE
• TERT-BUTYL-N-SUCCINIMIDYL N N'-ETHYLENE-
• N-SucciniMidoxycarbonyl-β-alanine N-SucciniMidyl Ester
• TERT-BUTYL N-SUCCINIMIDYL N,N'-HEXAMETHYLENEDICARBAMATE
• CARBAMIC ACID, (2-CHLOROETHYL)NITROSO-, 2,5-DIOXO-1-PYRROLIDINYL ESTER
• TERT-BUTYL N-SUCCINIMIDYL N,N'-TETRAMETHYLENEDICARBAMATE
• N-Succinimidyl-N-methylcarbamate