SHA 68 Chemical Properties

Boiling point:

727.8±60.0 °C(Predicted)

Density 

1.35±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMF: 16 mg/ml; DMSO: 14 mg/ml; Ethanol: 20 mg/ml; Ethanol:PBS (pH 7.2)(1:2): 0.33 mg/ml

form 

A crystalline solid

pka

13.32±0.40(Predicted)

color 

White to off-white

SHA 68 Usage And Synthesis

Description

SHA-68 is an antagonist of the neuropeptide S receptor (NPSR; IC₅₀s = 22 and 23.8 nM for the NPSR Asn¹⁰⁷ and NPSR Ile¹⁰⁷ isoforms, respectively). It is selective for NPSR over a panel of 14 G protein-coupled receptors exhibiting no activity at a concentration of 10 μM. SHA-68 (50 mg/kg) reduces NPS-induced horizontal activity and vertical rearing and climbing in mice. SHA-68 also reduces conditioned reinstatement of cocaine seeking in rats.

Uses

SHA 68 is a selective neuropeptide S antagonist.

storage

Store at +4°C

SHA 68(847553-89-3)Related Product Information

• SH-4-54
• SH5-07