Basic information Safety Supplier Related

SHA 68

Basic information Safety Supplier Related

SHA 68 Basic information

Product Name:
SHA 68
Synonyms:
  • SHA 68
  • N-(4-fluorobenzyl)-3-oxo-1,1-diphenyltetrahydro-1H-oxazolo[3,4-a]pyrazine-7(3H)-carboxamide
  • N-[(4-Fluorophenyl)methyl]tetrahydro-3-oxo-1,1-diphenyl-3H-oxazolo[3,4-a]pyrazine-7(1H)-carboxamide
  • 3H-Oxazolo[3,4-a]pyrazine-7(1H)-carboxamide, N-[(4-fluorophenyl)methyl]tetrahydro-3-oxo-1,1-diphenyl-
  • N-(4-Fluorobenzyl)-3-oxo-1,1-diphenyltetrahydro-3H-oxazolo[3,4-a]pyrazine-7(1H)-carboxamide
  • N-[(4-fluorophenyl)methyl]-3-oxo-1,1-diphenyl-hexahydro-1H-[1,3]oxazolo[3,4-a]pyrazine-7-carboxamide
CAS:
847553-89-3
MF:
C26H24FN3O3
MW:
445.49
Mol File:
847553-89-3.mol
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SHA 68 Chemical Properties

Boiling point:
727.8±60.0 °C(Predicted)
Density 
1.35±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 16 mg/ml; DMSO: 14 mg/ml; Ethanol: 20 mg/ml; Ethanol:PBS (pH 7.2)(1:2): 0.33 mg/ml
form 
A crystalline solid
pka
13.32±0.40(Predicted)
color 
White to off-white
InChI
InChI=1S/C26H24FN3O3/c27-22-13-11-19(12-14-22)17-28-24(31)29-15-16-30-23(18-29)26(33-25(30)32,20-7-3-1-4-8-20)21-9-5-2-6-10-21/h1-14,23H,15-18H2,(H,28,31)
InChIKey
SFRQIPRTNYHJHP-UHFFFAOYSA-N
SMILES
C12C(C3=CC=CC=C3)(C3=CC=CC=C3)OC(=O)N1CCN(C(NCC1=CC=C(F)C=C1)=O)C2
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SHA 68 Usage And Synthesis

Description

SHA-68 is an antagonist of the neuropeptide S receptor (NPSR; IC50s = 22 and 23.8 nM for the NPSR Asn107 and NPSR Ile107 isoforms, respectively). It is selective for NPSR over a panel of 14 G protein-coupled receptors exhibiting no activity at a concentration of 10 μM. SHA-68 (50 mg/kg) reduces NPS-induced horizontal activity and vertical rearing and climbing in mice. SHA-68 also reduces conditioned reinstatement of cocaine seeking in rats.

Uses

SHA 68 is a selective neuropeptide S antagonist.

in vivo

SHA 68 (i.p.; 5 and 50 mg/kg) reduces NPS-induced horizontal activity and vertical rearing and climbing[1].
SHA 68 (i.v.; 1 mg/kg) has a T1/2 of 0.74 hours, a CL of 4.29 mL/min/kg, and a Vss of 2.53 L/kg[1].
SHA 68 (i.p.; 2.5 mg/kg) has a T1/2 of 0.43 hours, a CL of 4.56 mL/min/kg[1].

Animal Model:Male C57BL/6 mice age 8-12 weeks[1]
Dosage:5 and 50 mg/kg
Administration:i.p.
Result:Reduced NPS-induced horizontal activity and vertical rearing and climbing.
Animal Model:Male C57BL/6 mice age 8-12 weeks[1]
Dosage:1 mg/kg (Pharmacokinetic Analysis)
Administration:i.p.
Result:Had a T1/2 of 0.74 hours, a CL of 4.29 mL/min/kg, and a Vss of 2.53 L/kg.

storage

Store at +4°C

References

[1] NAOE OKAMURA. Synthesis and pharmacological in vitro and in vivo profile of 3-oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-a]pyrazine-7-carboxylic acid 4-fluoro-benzylamide (SHA 68), a selective antagonist of the neuropeptide S receptor.[J]. Journal of Pharmacology and Experimental Therapeutics, 2008, 325 3: 893-901. DOI: 10.1124/jpet.107.135103
[2] MARSIDA KALLUPI. Neuropeptide S facilitates cue-induced relapse to cocaine seeking through activation of the hypothalamic hypocretin system.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2010: 19567-19572. DOI: 10.1073/pnas.1004100107

SHA 68Supplier

Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd Gold
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024-024-024-88590548 18341751992
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757984502@qq.com
Spectrum Chemical Manufacturing Corp.
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021-021-021-67601398-809-809-809 15221380277
Email
marketing_china@spectrumchemical.com
Shanghai Lollane Biological Technology Co.,Ltd.
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021-52996696，15000506266 15000506266
EMMX Biotechnology LLC
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888-539-0666
Email
info@emmx.com
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Email
3008007409@qq.com
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SHA 68(847553-89-3)Related Product Information