Basic information Safety Supplier Related

SRI-011381 (hydrochloride)

Basic information Safety Supplier Related

SRI-011381 (hydrochloride) Basic information

Product Name:
SRI-011381 (hydrochloride)
Synonyms:
  • SRI-011381 (hydrochloride)
  • SRI 011381 hydrochloride,multiple,Transforming growth factor beta,sclerosis,TGF-beta/Smad,α-SMA,NALP3,SRI 011381,collagen-1,SRI-011381,inhibit,TGF-β,neuroprotective,SRI011381,Inhibitor,SRI011381 hydrochloride
  • SRI-011381 hydrochloride, 10 mM in DMSO
CAS:
2070014-88-7
MF:
C20H32ClN3O
MW:
365.95
Mol File:
2070014-88-7.mol
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SRI-011381 (hydrochloride) Chemical Properties

storage temp. 
Store at -20°C
solubility 
DMSO : 33.33 mg/mL (91.08 mM)
form 
Solid
color 
White to off-white
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SRI-011381 (hydrochloride) Usage And Synthesis

Uses

SRI-011381 hydrochloride is an orally active TGF-β signaling agonist, exhibits neuroprotective effects[1][2].

in vivo

SRI-011381 (30 mg/kg; i.p.; every 2 d; for 22 days) hydrochloride partially rescues the deficits in optic nerve and retina of YAPGFAP-CKO EAE mice[2].

Animal Model:YAPGFAP-CKO mice bearing experimental autoimmune encephalomyelitis (EAE)[2]
Dosage:30 mg/kg
Administration:Intraperitoneally injection; every 2 d; for 22 days
Result:Significantly inhibited inflammatory infiltration and relieved the loss of neurons in YAPGFAP-CKO EAE mice.

References

[1] Jingyin Han, et al. The Improvement Effect of Sodium Ferulate on the Formation of Pulmonary Fibrosis in Silicosis Mice Through the Neutrophil Alkaline Phosphatase 3 (NALP3)/Transforming Growth Factor-β1 (TGF-β1)/α-Smooth Muscle Actin (α-SMA) Pathway. Med Sci Monit. 2021 Jun 15;27:e927978. DOI:10.12659/MSM.927978
[2] Qian Wu, et al. Astrocytic YAP protects the optic nerve and retina in an experimental autoimmune encephalomyelitis model through TGF-β signaling. Theranostics. 2021 Jul 25;11(17):8480-8499. DOI:10.7150/thno.60031

SRI-011381 (hydrochloride)Supplier

AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Email
info@adooq.cn
Shanghai RenYue Chemical Technology Co., Ltd.
Tel
021-62219190; 18321139117
Email
316441092@qq.com
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Email
info@efebio.com
Shanghai SuperLan Chemcial Technique Centre
Tel
0-2022843681 15618226720
Email
chaolaichem@foxmail.com
Angel Pharmatech, Ltd.
Tel
17317130613
Email
3358272972@qq.com
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SRI-011381 (hydrochloride)(2070014-88-7)Related Product Information