Mirogabalin besylate
Mirogabalin besylate Basic information
- Product Name:
- Mirogabalin besylate
- Synonyms:
-
- Mirogabalin besylate
- Mirogabalin besylat
- Mirogabalin Besilate
- MIROGABALIN BENZENESULFONIC ACID
- ((1R,5S,6S)-6-(carboxymethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl)methanaminium benzenesulfonate
- [(1R,5S,6S)-6-(Aminomethyl)-3-ethylbicyclo[3.2.0] hept-3-en-6-yl]acetic acid benzenesulfonate
- 2-((1R,5S,6S)-6-(aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl)acetic acid compound with benzenesulfonic acid (1:1)
- Mirogabalin Besylate 10928
- CAS:
- 1138245-21-2
- MF:
- C18H25NO5S
- MW:
- 367.46
- Mol File:
- 1138245-21-2.mol
Mirogabalin besylate Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- DMSO : 125 mg/mL (340.17 mM)
- InChI
- InChI=1/C12H19NO2.C6H6O3S/c1-2-8-3-9-5-12(7-13,6-11(14)15)10(9)4-8;7-10(8,9)6-4-2-1-3-5-6/h4,9-10H,2-3,5-7,13H2,1H3,(H,14,15);1-5H,(H,7,8,9)/t9-,10-,12-;/s3
- InChIKey
- OKJXJRVWXYRSAN-QWGAVYBYNA-N
- SMILES
- S(C1C=CC=CC=1)(O)(=O)=O.C([C@]1(C[C@@]2([H])CC(CC)=C[C@@]12[H])CN)C(=O)O |&1:11,13,20,r|
Mirogabalin besylate Usage And Synthesis
Description
Mirogabalin besylate (mirogabalin, Tarlige) is a gabapentinoid therapy developed by Daiichi Sankyo, which is approved in Japan for the treatment of postherpetic neuralgia and painful diabetic peripheral neuropathy. Mirogabalin has a potent pain-modulating effect with a unique high affinity and prolonged dissociation rate for the a2delta-1 subunit of voltage-gated calcium (Ca2+) channels (VGCCs) on the dorsal root ganglion resulting in more sustained analgesia compared with traditional gabapentinoids[1].
Side effects
Mirogabalin has a superior adverse events (AEs) profile due to a rapid dissociation from the a2delta-2 subunit of VGCCs potentially implicated in central nervous system-specific AEs. The most common AEs for mirogabalin are dizziness (approximately 8-16%), somnolence (approximately 6-24%) and headache (approximately 6-14%), with a lower incidence of constipation, nausea, diarrhea, vomiting, edema, fatigue and weight gain[1].
References
[1] J Burgess. “Mirogabalin besylate in the treatment of neuropathic pain.” Drugs of today 56 2 (2020): 135–149.
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