1H-Isoindole-1,3(2H)-dione, 2-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]- Chemical Properties

Boiling point:

565.6±50.0 °C(Predicted)

Density 

1.346±0.06 g/cm3(Predicted)

pka

7.86±0.10(Predicted)

1H-Isoindole-1,3(2H)-dione, 2-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]- Usage And Synthesis

Uses

5-HT6/7 antagonist 1 is a multifunctional ligand that antagonizes 5-HT6/7/2A and D2 receptors, without interacting with M1 receptors and hERG channels.

IC 50

5-HT₆ Receptor; 5-HT₇ Receptor; 5-HT_2A Receptor; D₂ Receptor

References

[1] Ko?aczkowski M, et al. Novel arylsulfonamide derivatives with 5-HT?/5-HT? receptor antagonism targeting behavioral and psychological symptoms of dementia. J Med Chem. 2014 Jun 12;57(11):4543-57. DOI:10.1021/jm401895u