H2N-PEG6-CH2COOtBu
H2N-PEG6-CH2COOtBu Basic information
- Product Name:
- H2N-PEG6-CH2COOtBu
- Synonyms:
-
- H2N-PEG6-CH2COOtBu
- NH2-PEG6-C1-Boc
- NH2CH2CH2(OCH2CH2)5OCH2CO2-t-Bu
- NH2-PEG6-CH2COOtBu
- tert-butyl 20-amino-3,6,9,12,15,18-hexaoxaicosanoate
- NH-2-PEG6-C1-Boc,PROTAC Linkers,Inhibitor,NH2 PEG6 C1 Boc,inhibit,NH2PEG6C1Boc
- H2N-PEG6-CH2COOtBu/3,6,9,12,15,18-Hexaoxaeicosanoic acid, 20-amino-, 1,1-dimethylethyl ester
- 3,6,9,12,15,18-Hexaoxaeicosanoic acid, 20-amino-, 1,1-dimethylethyl ester
- CAS:
- 297162-50-6
- MF:
- C18H37NO8
- MW:
- 395.48828
- Mol File:
- 297162-50-6.mol
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H2N-PEG6-CH2COOtBu Chemical Properties
- Boiling point:
- 463.4±40.0 °C(Predicted)
- Density
- 1.065±0.06 g/cm3(Predicted)
- pka
- 8.74±0.10(Predicted)
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H2N-PEG6-CH2COOtBu Usage And Synthesis
Biological Activity
NH2-PEG6-C1-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
H2N-PEG6-CH2COOtBuSupplier
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