t-Butoxycarbonyl-PEG4-sulfonic acid
t-Butoxycarbonyl-PEG4-sulfonic acid Basic information
- Product Name:
- t-Butoxycarbonyl-PEG4-sulfonic acid
- Synonyms:
-
- t-Butoxycarbonyl-PEG4-sulfonic acid
- Boc-PEG4-sulfonic acid
- 4,7,10,13-Tetraoxapentadecanoic acid, 15-sulfo-, 1-(1,1-dimethylethyl) ester
- CAS:
- 1817735-26-4
- MF:
- C15H30O9S
- MW:
- 386.46
- Mol File:
- 1817735-26-4.mol
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t-Butoxycarbonyl-PEG4-sulfonic acid Chemical Properties
- Density
- 1.194±0.06 g/cm3(Predicted)
- pka
- 1.34±0.50(Predicted)
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t-Butoxycarbonyl-PEG4-sulfonic acid Usage And Synthesis
Description
t-Butoxycarbonyl-PEG4-sulfonic acid is a PEG linker containing a t-butyl protecting group and sulfonic acid moiety. t-bytl can be removed under acidic conditions. Sulfonic acid groups can participate in esterification, halogenation and replacement reactions. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media.
Uses
Boc-PEG4-sulfonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
t-Butoxycarbonyl-PEG4-sulfonic acidSupplier
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