Prolyl Endopeptidase Inhibitor II Chemical Properties

Boiling point:

529.1±50.0 °C(Predicted)

Density 

1.312±0.06 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

DMSO: 10mg/mL
DMF: soluble
ethyl acetate: soluble

pka

-2.43±0.40(Predicted)

form 

oil

color 

colorless to off-white

Sequence

Z-Pro-Pro-CHO

Prolyl Endopeptidase Inhibitor II Usage And Synthesis

Uses

Z-Pro-Pro-CHO is a prolyl oligopeptidase inhibitor (IC50: 0.16 μM and 0.01 μM for human and Schistosoma Mansoni prolyl oligopeptidase respectively)[1].

Biological Activity

Cell permeable: yes', 'Primary Target
Mouse brain prolylendooeotidase', 'Product does not compete with ATP.', 'Reversible: no', 'Target Ki: 350 pM and 500 pM for mouse brain and human brain prolyl endopeptidase, respectively

IC 50

Schistosome

References

[1] Fajtová P, et al. Prolyl Oligopeptidase from the Blood Fluke Schistosoma mansoni: From Functional Analysis to Anti-schistosomal Inhibitors. PLoS Negl Trop Dis. 2015 Jun 3;9(6):e0003827. DOI:10.1371/journal.pntd.0003827