DORA-22
DORA-22 Basic information
- Product Name:
- DORA-22
- Synonyms:
-
- DORA-22
- [(2R,5R)-5-[(5-FLUOROPYRIDIN-2-YL)OXYMETHYL]-2-METHYLPIPERIDIN-1-YL]-(5-FLUORO-2-PYRIMIDIN-2-YLPHENYL)METHANONE
- DORA 22,DORA22
- Methanone, [(2R,5R)-5-[[(5-fluoro-2-pyridinyl)oxy]methyl]-2-methyl-1-piperidinyl][5-fluoro-2-(2-pyrimidinyl)phenyl]-
- DORA-22, 10 mM in DMSO
- CAS:
- 1088991-95-0
- MF:
- C23H22F2N4O2
- MW:
- 424.44
- Mol File:
- 1088991-95-0.mol
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DORA-22 Chemical Properties
- Boiling point:
- 524.3±50.0 °C(Predicted)
- Density
- 1.258±0.06 g/cm3(Predicted)
- pka
- 1.54±0.22(Predicted)
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DORA-22 Usage And Synthesis
Description
DORA-22 is an orexin receptor antagonist.
Uses
DORA-22 is an orally active dual orexinergic receptor antagonist, and improves the sleep disruption and memory impairment. DORA-22 can be used for study of insomnia[1][2].
References
[1] Gamble MC, et al. The dual orexinergic receptor antagonist DORA-22 improves the sleep disruption and memory impairment produced by a rodent insomnia model. Sleep. 2020;43(3):zsz241. DOI:10.1093/sleep/zsz241
[2] Lin Y, Ret al. Positive allosteric adenosine A2A receptor modulation suppresses insomnia associated with mania- and schizophrenia-like behaviors in mice. Front Pharmacol. 2023;14:1138666. Published 2023 Apr 19. DOI:10.3389/fphar.2023.1138666
DORA-22Supplier
Nanjing Norris-Pharm Technology Co., Ltd
- Tel
- 18652989687
- sales@norris-pharm.com
Shanghai Changyan Chem & Tech Co., Ltd.
- Tel
- 021-20242659 18930833303
- Sales@changyanchem.cn
ShangHai Biochempartner Co.,Ltd
- Tel
- 177-54423994 17754423994
- 2853530910@QQ.com
Jinan Yaoyan Pharmaceutical Co., Ltd.
- Tel
- jnyaoyan@163.com
Nanjing Meihao Pharmaceutical Technology Co., Ltd.
- Tel
- meitaochem@126.com
- meitaochem@126.com