Basic information Safety Supplier Related

SR 57227 HYDROCHLORIDE

Basic information Safety Supplier Related

SR 57227 HYDROCHLORIDE Basic information

Product Name:
SR 57227 HYDROCHLORIDE
Synonyms:
  • sr57227a
  • 1-(6-CHLORO-2-PYRIDINYL)-4-PIPERIDINAMINE HYDROCHLORIDE
  • 4-AMINO-1-(6-CHLORO-2-PYRIDYL)-PIPERIDINE HYDROCHLORIDE
  • SR 57227A HYDROCHLORIDE
  • SR 57227 HYDROCHLORIDE
  • SR57227HCl
  • CM-57277
  • 1-(6-chloropyridin-2-yl)piperidin-4-amine hydrochloride
CAS:
77145-61-0
MF:
C10H15Cl2N3
MW:
248.15
Product Categories:
  • Serotonin receptor
Mol File:
77145-61-0.mol
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SR 57227 HYDROCHLORIDE Chemical Properties

storage temp. 
Store at RT
solubility 
H2O: 9 mg/mL, soluble
form 
solid
color 
white
Water Solubility 
H2O: soluble 9mg/mL
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Safety Information

Hazard Codes 
T
Risk Statements 
25-36/37/38
Safety Statements 
26-45
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
TM3465250

MSDS

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SR 57227 HYDROCHLORIDE Usage And Synthesis

Uses

SR 57227A acts as highly potent and shows high affinity for the 5-HT3 receptor agonist.

Biological Activity

A high affinity, selective 5-HT 3 receptor agonist, active in vivo and CNS penetrant.

in vivo

SR 57227A (1-30 mg/kg; i.p.) dose-dependently reduces immobility time in the forced swimming test with an ED50 value for this effect of 14.2 mg/kg[2].
In the forced swimming test, SR 57227A dose-dependently reduces the duration of immobility in rats after i.p. administration. (ED50=7.6 mg/kg i.p. in rats.) SR 57227A is also active in both species after oral administration. In a time-course study in mice, SR 57227A (20 mg/kg p.o.) produces a significant effect lasting 6 hours. SR 57227A (1 and 3 mg/kg i.p.) reduces the elevation of the escape failures in the learned helplessness model in rats by 50-60% on the last two days of the avoidance task, and reduces isolation-induced aggressivity in mice by 50 to 85%, an effect which is antagonised by Zacopride (1 mg/kg i.p.)[2].

storage

Store at RT

SR 57227 HYDROCHLORIDESupplier

3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Email
3bsc@sina.com
EMMX Biotechnology LLC
Tel
888-539-0666
Email
info@emmx.com
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Email
info@efebio.com
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Email
3008007409@qq.com
Tianjin Kailiqi Biotechnology Co., Ltd.
Tel
15076683720
Email
klq@cw-bio.com
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