ANTI-TIA-1
ANTI-TIA-1 Basic information
- Product Name:
- ANTI-TIA-1
- Synonyms:
-
- Anti-TIA1 antibody produced in rabbit
- Anti-TIA1 antibody produced in goat
- ANTI-TIA-1
- ANTI-TIA-1/GMP-17
- Anti-Cytotoxic granule-associated RNA-binding protein
- Anti-p40-TIA-1
- Anti-TIA1 cytotoxic granule-associated RNA binding protein
- MW:
- 0
- Mol File:
- Mol File
ANTI-TIA-1 Chemical Properties
- storage temp.
- -20°C
- form
- buffered aqueous solution
- biological source
- rabbit
ANTI-TIA-1 Usage And Synthesis
Biological Activity
TIA1 is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested th at this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein th at is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing.The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested th at this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein th at is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms of this gene product has been described in the literature.