4-(CHLOROMETHYL)-3,5-DIMETHYLISOXAZOLE Chemical Properties

Melting point:

88-90°C

Boiling point:

87-88 °C/8 mmHg (lit.)

Density 

1.173 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.486(lit.)

Flash point:

204 °F

storage temp. 

2-8°C

pka

-1.73±0.28(Predicted)

form 

clear liquid

color 

Light yellow to Brown

BRN 

110780

CAS DataBase Reference

19788-37-5(CAS DataBase Reference)

EPA Substance Registry System

Isoxazole, 4-(chloromethyl)-3,5-dimethyl- (19788-37-5)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

20/21/22-36/37/38-37/38-36

Safety Statements 

26-36

RIDADR 

UN 3334

WGK Germany 

3

TSCA 

Yes

HazardClass 

IRRITANT

HS Code 

29349990

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

4-(CHLOROMETHYL)-3,5-DIMETHYLISOXAZOLE Usage And Synthesis

Chemical Properties

Colorless to yellow liquid

Uses

4-Chloromethyl-3,5-dimethylisoxazole has been used in the preparation of:

• 4(3-oxoalkyl)isoxazole
• (E)-3,5-dimethyl-4-(2-(thiophene-3-yl)vinyl)isoxazole

Application

4-(Chloromethyl)-3,5-dimethylisoxazole is an annulation reagent used for the construction of cyclohexenones in the syntheses of steroids, terpenes, and alkaloids.

General Description

4-Chloromethyl-3,5-dimethylisoxazole participates in asymmetric isoxazole annulation reaction.

storage

Handling, Storage, and Precautions of 4-(Chloromethyl)-3,5-dimethylisoxazole: light-sensitive lachrymator; refrigerate; handle and store under nitrogen.

4-(CHLOROMETHYL)-3,5-DIMETHYLISOXAZOLE(19788-37-5)Related Product Information

• 3,5-Dimethylisoxazole
• Isoxazole
• 3-(4-METHOXYPHENYL)-5-METHYL-4-ISOXAZOLECARBONYL CHLORIDE
• 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carbonyl chloride
• 3,5-DIMETHYLISOXAZOLE-4-CARBONYL CHLORIDE
• 3-(2,6-Dichlorophenyl)-5-methylisoxazole-4-carbonyl chloride
• 3-METHYL-5-PHENYL-4-ISOXAZOLECARBONYL CHLORIDE
• 4-(CHLOROMETHYL)-3,5-DIMETHYLISOXAZOLE
• 3-(2-Chlorophenyl)-5-methylisoxazole-4-carbonyl chloride
• 5-Methyl-3-phenylisoxazole-4-carbonyl chloride
• 3-(4-FLUOROPHENYL)-5-METHYL-4-ISOXAZOLECARBONYL CHLORIDE
• 3-METHYL-5-(5-METHYLISOXAZOL-3-YL)ISOXAZOL-4-CARBONYLCHLORIDE
• 3-METHYL-5-(4-METHYL-1,2,3-THIADIAZOL-5-YL)-4-ISOXAZOLECARBONYL CHLORIDE
• 4-CHLOROMETHYL-5-METHYL-ISOXAZOLE-3-CARBOXYLIC ACID ETHYL ESTER
• 4-(CHLOROMETHYL)-3-(2,6-DICHLOROPHENYL)-5-METHYLISOXAZOLE
• 3-METHYL-5-(TRIFLUOROMETHYL)ISOXAZOLE-4-CARBONYL CHLORIDE
• 4-[CHLORO(PHENYL)METHYL]-3-(2,6-DICHLOROPHENYL)-5-METHYLISOXAZOLE