MMP-9/MMP-13 INHIBITOR I Chemical Properties

Density 

1.364±0.06 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

Soluble in DMSO or methanol

pka

9.38±0.23(Predicted)

form 

Solid

color 

White to off-white

Sensitive 

Light Sensitive

MMP-9/MMP-13 INHIBITOR I Usage And Synthesis

Description

MMP-9/MMP-13 inhibitor I is a cell-permeable inhibitor of matrix metalloproteinases (MMPs) that most potently inhibits MMP-9 and MMP-13 (IC₅₀s = 0.9 nM for both). It less effectively inhibits MMP-1, MMP-3, and MMP-7 (IC₅₀s = 43, 23, and 920 nM, respectively). MMP-9/MMP-13 inhibitor I has been used to elucidate the roles of MMPs in biological systems, including tumor cell invasion and pathogenesis of P. falciparum.

Uses

A piperazine-based, cell-permeable, and highly potent inhibitor of MMP-9 and MMP-13