3-PHENYL-PYRIDIN-2-YLAMINE Chemical Properties

Boiling point:

320.3±22.0 °C(Predicted)

Density 

1.133

storage temp. 

2-8°C(protect from light)

pka

6.29±0.36(Predicted)

Appearance

White to light yellow Solid

Safety Information

HS Code 

2933399990

3-PHENYL-PYRIDIN-2-YLAMINE Usage And Synthesis

Synthesis

General procedure for the synthesis of 2-amino-3-phenylpyridine from 2-amino-3-bromopyridine and phenylboronic acid: to a solution of 2-amino-3-bromopyridine (3 mmol, 0.5 g) in ethylene glycol (5 mL) was added phenylboronic acid (4.5 or 9.0 mmol, 1.5 or 3 eq.), tetrakis(triphenylphosphine)palladium(0) (1 mol%) and potassium phosphate (6 mmol, 6 eq.) in sequence. 2 eq.) in water (2 mL). The reaction mixture was heated at 80 °C for 16 h. After completion of the reaction, it was hydrolyzed with 1 M sodium hydroxide solution (20 mL). The aqueous phase was extracted with ethyl acetate (3 x 30 mL) and the combined organic layers were washed with saturated sodium chloride solution (50 mL), dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography using petroleum ether/ethyl acetate (60/40, v/v) as eluent.

References

[1] Chemistry - A European Journal, 2013, vol. 19, # 28, p. 9137 - 9141
[2] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 1, p. 114 - 120
[3] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 4, p. 911 - 917
[4] Patent: WO2011/17342, 2011, A2. Location in patent: Page/Page column 116
[5] Patent: WO2015/148344, 2015, A2. Location in patent: Page/Page column 60

3-PHENYL-PYRIDIN-2-YLAMINE(87109-10-2)Related Product Information

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• 4-PHENYL-PYRIDIN-3-YLAMINE DIHYDROCHLORIDE