(RS)-1-(2-AMINO-2-CARBOXYETHYL)-3-(2-CARBOXYBENZYL)PYRIMIDINE-2,4-DIONE Chemical Properties

Melting point:

190.8-191.2 °C (decomp)(Solv: water (7732-18-5))

Boiling point:

603.0±65.0 °C(Predicted)

Density 

1.525±0.06 g/cm3(Predicted)

storage temp. 

Store at RT

solubility 

<3.33mg/ml in 1eq. NaOH; <3.33mg/ml in DMSO

pka

2.12±0.10(Predicted)

(RS)-1-(2-AMINO-2-CARBOXYETHYL)-3-(2-CARBOXYBENZYL)PYRIMIDINE-2,4-DIONE Usage And Synthesis

Uses

UBP 296 is a novel, potent and selective kainate receptor antagonist.

Definition

ChEBI: 2-[[3-(2-amino-2-carboxyethyl)-2,6-dioxo-1-pyrimidinyl]methyl]benzoic acid is an alpha-amino acid.

Biological Activity

Selective and potent GluR5-subunit containing kainate receptor antagonist (apparent K D = 1.09 mM). Displays ~ 90-fold selectivity over AMPA receptors and recombinant human GluR6- and KA2-containing kainate receptors. Has little or no action at NMDA or group I mGlu receptors. Selectively blocks kainate receptor-mediated LTP induction in rat hippocampal mossy fibres.

storage

Store at RT