LSZ-102
LSZ-102 Basic information
- Product Name:
- LSZ-102
- Synonyms:
-
- LSZ-102
- LSZ102;LSZ-102;LSZ 102
- CS-2791
- 2-Propenoic acid, 3-[4-[[2-[2-(1,1-difluoroethyl)-4-fluorophenyl]-6-hydroxybenzo[b]thien-3-yl]oxy]phenyl]-, (2E)-
- LSZ-102, 10 mM in DMSO
- (2E)-3-[4-[[2-[2-(1,1-Difluoroethyl)-4-fluorophenyl]-6-hydroxybenzo[b]thien-3-yl]oxy]phenyl]-2-propenoic acid
- CAS:
- 2135600-76-7
- MF:
- C25H17F3O4S
- MW:
- 470.46
- Product Categories:
-
- APIs
- Mol File:
- 2135600-76-7.mol
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LSZ-102 Chemical Properties
- Boiling point:
- 643.5±55.0 °C(Predicted)
- Density
- 1.418±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- pka
- 4.49±0.10(Predicted)
- color
- White to light yellow
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LSZ-102 Usage And Synthesis
Uses
is a potent, orally bioavailable selective estrogen receptor degrader currently being studied for the treatment of ERα positive breast cancer.
in vivo
Treatment of the mice with LSZ-102 once daily at 20 mg/kg results in significant tumor growth inhibition as compare to the control group treated with vehicle alone, resulting in tumor stasis (mean change in tumor volume of LSZ-102 vs control=%ΔT/ΔC of 2.4% on day 48, p<0.05). Dosing of 3 mg/kg solution of LSZ-102 in male Sprague-Dawley rats results in 33% bioavailability and a dose-normalized exposure of 620 nM h[1].
LSZ-102Supplier
Nanjing Chemlin Chemical Co., Ltd
- Tel
- 025-83697070
- info@chemlin.com.cn
ShangHai Caerulum Pharma Discovery Co., Ltd.
- Tel
- 18149758185
- sales-cpd@caerulumpharma.com
Shanghai Lollane Biological Technology Co.,Ltd.
- Tel
- 021-52996696，15000506266 15000506266
ShangHai Biochempartner Co.,Ltd
- Tel
- 177-54423994 17754423994
- 2853530910@QQ.com
Tianjin Kaifu Pharmaceutical Technology Co., Ltd.
- Tel
- 18081075745
- chemflowtech@sina.com