SJ000291942 Chemical Properties

Boiling point:

525.4±50.0 °C(Predicted)

Density 

1.327±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMF: 30 mg/ml; DMSO: 30 mg/ml

form 

A crystalline solid

pka

11.44±0.70(Predicted)

color 

White to off-white

SJ000291942 Usage And Synthesis

Uses

2-(4-Ethylphenoxy)-N-(4-fluoro-3-nitrophenyl)acetamide is a canonical bone morphogenetic proteins (BMP) signaling pathway activator.

Biological Activity

SJ000291942 is an activator of Bone Morphogenetic Protein (BMP) signaling with an EC50 value < 1 μM. Bone Morphogenetic Proteins (BMPs) are a group of growth factors and cytokines were originally discovered by their ability to induce the formation of bone and cartilage, but are now considered to constitute a group of pivotal morphogenetic signals, orchestrating tissue architecture throughout the body. SJ000291942 was shown to ventralize zebrafish embryos, activate SMAD1/5/8 phosphorylation, and induce the differentiation of C2C12 myoblasts to osteoblasts in manner consistent with BMP4 activation.