13C C16 Sphingomyelin (d18:1/16:0) Chemical Properties

storage temp. 

Store at -20°C

solubility 

Chloroform: soluble; Ethanol: soluble; Methanol: soluble

form 

A solid

13C C16 Sphingomyelin (d18:1/16:0) Usage And Synthesis

Description

C16 Sphingomyelin-¹³C (d18:1/16:0-¹³C) is intended for use as an internal standard for the quantification of C16sphingomyelin by GC- or LC-MS. C16 Sphingomyelin is a naturally occurring sphingolipid. Levels of C16 sphingomyelin are elevated in the prefrontal cortex and cerebellum in a rat model of diabetes induced by streptozotocin (STZ; ), as well as in the liver in mouse models of Niemann-Pick type C1 disease. Plasma levels of C16 sphingomyelin are decreased in patients with prostate cancer. Model membranes containing C16 sphingomyelin, 1-palmitoyl-2-oleoyl-sn-glycero-3-PC (POPC; ), and cholesterol have been used in the study of lipid raft dynamics and membrane organization. [Matreya, LLC. Catalog No. 2200]

Uses

N-Palmitoyl-D-sphingomyelin-13C is a deuterated labeled N-Palmitoyl-D-sphingomyelin[1]. N-Palmitoyl-D-sphingomyelin (Sphingomyelin 16:0) (Compound SM-03) can be used for the synthesis of lipid nanoparticles[2].

References

[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. DOI:10.1177/1060028018797110
[2] Dandan LING, et al. Lipid compounds and lipid nanoparticle compositions. Patent. WO2023056914.