BMS-8 Chemical Properties

Boiling point:

616.9±55.0 °C(Predicted)

Density 

1.334±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

Methanol: slightly soluble

form 

A crystalline solid

pka

2.35±0.20(Predicted)

color 

White to off-white

BMS-8 Usage And Synthesis

Description

BMS-8 is a small molecule inhibitor of the protein-protein interaction between programmed death protein 1 (PD-1) and its ligand programmed cell death ligand 1 (PD-L1) with an IC₅₀ value of 146 nM in a homogeneous time-resolved fluorescence (HTRF) binding assay.

Uses

BMS-8 is inhibitor of the PD-1/PD-L1 interaction by inducing PD-L1 dimerization through PD-1 interacting surface, binding at a hydrophobic cavity formed upon PD-L1 dimerization.