2'-Chloro-N6-cyclopentyl-2'-fluoro-beta-D-arabinoadenosine
2'-Chloro-N6-cyclopentyl-2'-fluoro-beta-D-arabinoadenosine Basic information
- Product Name:
- 2'-Chloro-N6-cyclopentyl-2'-fluoro-beta-D-arabinoadenosine
- Synonyms:
-
- 2'-Chloro-N6-cyclopentyl-2'-fluoro-beta-D-arabinoadenosine
- 2-Chloro-N6-cyclopentyl-2'-deoxy-2'-fluoro-beta-D-arabinoadenosine
- 9H-Purin-6-amine, 2-chloro-N-cyclopentyl-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-
- 2-Chloro-N6-cyclopentyl-2’-fluoro-β-D-arabinoadenosine
- (2R,3R,4S,5R)-5-[2-chloro-6-(cyclopentylamino)purin-9-yl]-4-fluoro-2-(hydroxymethyl)oxolan-3-ol
- 2-Chloro-N6-cyclopentyl-2’-deoxy-2’-fluoro-beta-D-arabinoadenosine
- (2R,3R,4S,5R)-5-(2-chloro-6-(cyclopentylamino)-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)tetrahydrofuran-3-ol
- CAS:
- 2216764-33-7
- MF:
- C15H19ClFN5O3
- MW:
- 371.8
- Mol File:
- 2216764-33-7.mol
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2'-Chloro-N6-cyclopentyl-2'-fluoro-beta-D-arabinoadenosine Chemical Properties
- Boiling point:
- 583.7±60.0 °C(Predicted)
- Density
- 1.83±0.1 g/cm3(Predicted)
- pka
- 12.57±0.70(Predicted)
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2'-Chloro-N6-cyclopentyl-2'-fluoro-beta-D-arabinoadenosine Usage And Synthesis
Uses
2-Chloro-N6-cyclopentyl-2’-deoxy-2’-fluoro-beta-D-arabinoadenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
References
[1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005
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