TRPM8 Antagonist
TRPM8 Antagonist Basic information
- Product Name:
- TRPM8 Antagonist
- Synonyms:
-
- TRPM8 Antagonist
- TRPM8 ANTAGONIST;259674-19-6
- TRPM8 antagonist 2
- L-Tryptophan, N,N-bis(phenylmethyl)-, methyl ester
- Methyl N,N-dibenzyl-L-tryptophanate
- Methyl Na,Na-dibenzyl-L-tryptophanate
- TRPM8 antagonist 2,inhibit,Transient receptor potential channels,TRP Channel,Inhibitor,TRPM-8 antagonist 2
- TRPM8 antagonist 2, 10 mM in DMSO
- CAS:
- 259674-19-6
- MF:
- C26H26N2O2
- MW:
- 398.5
- Product Categories:
-
- API
- Mol File:
- 259674-19-6.mol
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TRPM8 Antagonist Chemical Properties
- Boiling point:
- 567.5±50.0 °C(Predicted)
- Density
- 1.195±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- DMSO : 160 mg/mL (401.51 mM)
- pka
- 17.02±0.30(Predicted)
- form
- Solid
- color
- Light yellow to yellow
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TRPM8 Antagonist Usage And Synthesis
Uses
TRPM8 antagonist 2 is a potent and selective TRPM8 antagonist, with an IC50 of 0.2 nM, used in the research of neuropathic pain syndromes.
in vivo
TRPM8 antagonist 2 (1, 10, and 30 mg/kg, s.c.) shows a marked, dose-dependent antinociceptive activity, and inhibits wet-dog shakes (WDS)-like cold hypersensitivity in mice by 63% at 30 mg/kg. In addition, TRPM8 antagonist 2 (0.1 and 1 μg, s.c.) attenuates Oxaliplatin (OXP)-induced cold allodynia in mice[1].
References
[1] Bertamino A, et al. Identification of a Potent Tryptophan-Based TRPM8 Antagonist With in Vivo Analgesic Activity. J Med Chem. 2018 Jul 10. doi: 10.1021/acs.jmedchem.8b00545. DOI:10.1021/acs.jmedchem.8b00545
TRPM8 AntagonistSupplier
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