CYS-TYR-ILE-THR-ASN-CYS-GLY-LEU-GLY-NH2
CYS-TYR-ILE-THR-ASN-CYS-GLY-LEU-GLY-NH2 Basic information
- Product Name:
- CYS-TYR-ILE-THR-ASN-CYS-GLY-LEU-GLY-NH2
- Synonyms:
-
- thr(4)-gly(7)-oxytoci
- [THR4, GLY7] OT
- [THR4, GLY7]-OXYTOCIN
- CYS-TYR-ILE-THR-ASN-CYS-GLY-LEU-GLY-NH2
- H-CYS-TYR-ILE-THR-ASN-CYS-GLY-LEU-GLY-NH2
- H-CYS-TYR-ILE-THR-ASN-CYS-GLY-LEU-GLY-NH2, (DISULFIDE BOND)
- 3,3-DiallylthiacarbocyanineBromide
- Cys-Tyr-Ile-Thr-Asn-Cys-Gly-Leu-Gly-NH2 (Disulfide bridge Cys1-Cys6)
- CAS:
- 60786-59-6
- MF:
- C39H61N11O12S2
- MW:
- 940.1
- Mol File:
- 60786-59-6.mol
CYS-TYR-ILE-THR-ASN-CYS-GLY-LEU-GLY-NH2 Chemical Properties
- Boiling point:
- 1489.4±65.0 °C(Predicted)
- Density
- 1.265±0.06 g/cm3(Predicted)
- storage temp.
- −20°C
- form
- Solid
- pka
- 9.90±0.15(Predicted)
- color
- White to off-white
Safety Information
- Hazard Codes
- Xn
- Risk Statements
- 20
- Safety Statements
- 36/37/39-45
- WGK Germany
- 3
MSDS
- Language:English Provider:SigmaAldrich
CYS-TYR-ILE-THR-ASN-CYS-GLY-LEU-GLY-NH2 Usage And Synthesis
Uses
(Thr4,Gly7)-Oxytocin, an Oxytocin analogue, is a specific OT receptor agonist. (Thr4,Gly7)-Oxytocin also excites subicular neurons via activation of TRPV1 channels, and depression of K+ channels. [1][2].
in vivo
(Thr4,Gly7)-Oxytocin (1 μM, direct intra-PVT infusion for 1 min) evokes depolarization on TGOT-responsive neurons in mice[1].
(Thr4,Gly7)-Oxytocin (100 ng, intracerebroventrical injection) increases nitric oxide production in the paraventricular nucleus of the hypothalamus of male rats[3].
| Animal Model: | Swiss Webster mice [1] |
| Dosage: | 1 μM |
| Administration: | Intratracheal administration for 24 h |
| Result: | Excited 34.3% of aPVT neurons, 57.6% of mPVT neurons, and 60.0% of pPVT neurons. Increased the firing rate of TGOT-responsive PVT neurons in all subregions. |
References
[1] Lily R Barrett, et al. Oxytocin activation of paraventricular thalamic neurons promotes feeding motivation to attenuate stress-induced hypophagia. Neuropsychopharmacology. 2021 Apr;46(5):1045-1056. DOI:10.1038/s41386-021-00961-3
[2] Binqi Hu, et al. Activation of Oxytocin Receptors Excites Subicular Neurons by Multiple Signaling and Ionic Mechanisms. Cereb Cortex. 2021 Mar 31;31(5):2402-2415. DOI:10.1093/cercor/bhaa363
[3] M R Melis, et al. Oxytocin increases nitric oxide production in the paraventricular nucleus of the hypothalamus of male rats: correlation with penile erection and yawning. Regul Pept. 1997 Mar 26;69(2):105-11. DOI:10.1016/s0167-0115(97)00002-5
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