Oxytocin acetate Chemical Properties

storage temp. 

Store at -20°C

solubility 

DMSO:44.0(Max Conc. mg/mL);41.23(Max Conc. mM)
Water:50.0(Max Conc. mg/mL);46.85(Max Conc. mM)

form 

A crystalline solid

color 

White to off-white

InChIKey

DSZOEVVLZMNAEH-SIVBSZNNNA-N

Safety Information

RIDADR 

UN 2811 6.1 / PGII

HS Code 

2937190000

Oxytocin acetate Usage And Synthesis

Description

Oxytocin acetate is an analog of oxytocin, a hormone that stimulates the uterus during labor. It is synthesized by chemically conjugation oxytocin with acetic acid. The stability of this molecule has been proven to be higher than that of oxytocin. This drug demonstrates a stronger binding affinity for the oxytocin receptor, which may be attributed to its increased molecular weight. Additionally, oxytocin acetate has been observed to increase levels of growth factors and fatty acids in tissues when administered intramuscularly, while also stimulating neurotransmission. It exhibits a shorter onset latency and a longer duration of action compared to other analogs. Apart from its medical applications, oxytocin acetate can also serve as a disinfectant in cosmetic use and as an amide-forming agent in organic synthesis reactions.

Chemical Properties

White Solid

Uses

Oxytocin Acetate is the principal uterus-contracting and lactation-stimulating hormone of the posterior pituitary gland.

Uses

Oxytocin acetate is the salt form of oxytocin and has a more stable structure than oxytocin. Oxytocin is a cyclic nonpeptide that is recommended by the World Health Organization (WHO) for the prevention and treatment of postpartum haemorrhage. Oxytocin is used to therapeutically induce labour and stimulate lactation, and is also the drug of choice for the prevention of postpartum haemorrhage. Oxytocin has also recently been tested for the treatment of social phobia, autism, alcoholism and schizophrenia, and has been investigated for its potential modulatory role in antinociception^[1].

Mechanism of action

The actions of oxytocin are mediated by a single G protein-coupled receptor distributed in many peripheral tissues and specific brain areas. Oxytocin secreted into the circulation stimulates uterine contractions during labor and stimulates milk ejection during lactation.

References

[1] MOSTAFA GHASEMISARABBADIEH; Benjamín R S; Sveinbj?rn Gizurarson. The effect of trehalose, antioxidants, and acetate buffer concentration on oxytocin stability[J]. Journal of Peptide Science, 2021. DOI:10.1002/psc.3324.

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