Exenatide acetate Chemical Properties

Melting point:

>209°C (dec.)

storage temp. 

Refrigerator, under inert atmosphere

solubility 

Acetonitrile (Slightly), Water (Slightly)

form 

Solid

color 

White to Off-White

Sequence

H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2

CAS DataBase Reference

141732-76-5(CAS DataBase Reference)

Exenatide acetate Usage And Synthesis

Chemical Properties

Exenatide acetate is White Solid

Uses

A 39-amino acid peptide originally isolated from the salivary glands of the Gila monster (Heloderma suspectum), differs from exendin-3 only in two positions close to the N-terminus. Application of exenatide causes an increase in acinar cAMP without stimulating amylase release. As an incretin mimetic, exenatide acts as agonist of the glucagon-like peptide-1 (GLP-1) receptor. As GLP-1, though with prolonged activity, exenatide augments the postprandial production of insulin and suppresses secretion of glucagon. For this reason, exenatide has found use as a medication of diabetes II.

Uses

Application of exenatide acetate causes an increase in acinar cAMP without stimulating amylase release. As an incretin mimetic, exenatide acetate acts as agonist of the glucagon-like peptide-1 (GLP-1) receptor. As GLP-1, though with prolonged activity, exenatide acetate augments the postprandial production of insulin and suppresses secretion of glucagon. For this reason, exenatide acetate has found use as a medication of diabetes II.

Clinical Use

39-peptide known as an incretin mimetic; an agonist of glucagon-like peptide-1, used adjunctively in type II diabetes mellitus.

Drug interactions

Potentially hazardous interactions with other drugs
Anticoagulants: possibly enhances anticoagulant effect of warfarin.
Other nephrotoxins: avoid concomitant use.

Metabolism

Exenatide is eliminated through the kidneys by glomerular filtration followed by proteolytic degradation.

Exenatide acetate(141732-76-5)Related Product Information

• Butyl acetate
• Sodium acetate
• Potassium Acetate
• Glatiramer acetate
• Exendin-4
• Vinyl acetate
• Octreotide acetate
• Ethyl acetate
• Methyl acetate
• Tocopheryl acetate
• Pramlintide acetate
• HOE-140
• ACETATE
• Aluminum acetylacetonate
• DICHLORO(ETHYLENEDIAMINE)PLATINUM(II)
• COBALT(II) ACETYLACETONATE
• Tosylmethyl isocyanide
• 2,4-PENTANEDIONE, SILVER DERIVATIVE