CD44 ANTIBODY Usage And Synthesis

Source

Rabbit

Applications

Staining antibody. For staining, use 10µl/1,000,000 cells.

Reactivity

Human

Immunogen

Purified human T-Cells.

Background

CD44 is a cell-surface glycoprotein that plays a role in cell-cell interactions, cell adhesion and migration. CD44 is a receptor for hyaluronic acid and also interacts with other ligands, such as osteopontin, collagens, and matrix metalloproteinases. CD44 participates in a wide variety of cellular functions such as lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis.
CD44 and CD49d are putative activity markers and CD44 a potential novel therapeutic target in multiple sclerosis. Increased CD44 antigen is associated with relapses in non-small cell lung cancers.

References

[1] Goodison, S. et al. (1999) Mol. Pathol. 52, 189-196.
[2] Cichy, J. and Puré, E. (2003) J. Cell Biol. 161, 839-843.
[3] Bourguignon, L.Y. et al. (1997) J. Biol. Chem. 272, 27913-27918.
[4] Legg, J.W. et al. (2002) Nat. Cell Biol. 4, 399-407.
[5] Yonemura, S. et al. (1998) J. Cell Biol. 140, 885-895.
[6] Tsukita, S. et al. (1994) J. Cell Biol. 126, 391-401.