CGS 15435
CGS 15435 Basic information
- Product Name:
- CGS 15435
- Synonyms:
-
- CGS 15435
- 1H-Indole-3-hexanoic acid, 5-chloro-1-methyl-2-(3-pyridinyl)-
- CGS 15435, 10 mM in DMSO
- CAS:
- 95853-92-2
- MF:
- C20H21ClN2O2
- MW:
- 356.85
- Mol File:
- 95853-92-2.mol
CGS 15435 Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
CGS 15435 Usage And Synthesis
Uses
CGS 15435, is a thromboxane (TxA2) synthetase inhibitor. It has also high selectivity for Tx synthetase 100000-fold greater than that for cyclooxygenase, PGI2 synthetase and lipoxygenase enzymes.
in vivo
CGS 15435 has a long duration of action, since the increases in the plasma levels of TxB2 are prevented even at 24 h after CGS 15435 administration. CGS 15435 significantly inhibits TxB2 formation 4, 6, 12 and 24 h after dosing. Administration of CGS 15435 0.25 or 24 h prior to Arachidonic acid (AA) produced no increase in TxB2 in the surviving animals (4/4 and 5/6, respectively). The final TxB2 levels in the CGS15435A (0.25 and 24 h pretreatment) groups are significantly lower (P<0.05) than those seen in the AA or the Dazoxiben (2 h pretreatment) groups[1].
IC 50
TXA2: 1 nM (IC50)
CGS 15435Supplier
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