SW-100
SW-100 Basic information
- Product Name:
- SW-100
- Synonyms:
-
- SW-100
- Benzamide, 4-[(6-chloro-3,4-dihydro-1(2H)-quinolinyl)methyl]-N-hydroxy-
- 4-((6-CHLORO-3,4-DIHYDROQUINOLIN-1(2H)-YL)METHYL)-N-HYDROXYBENZAMIDE
- HDAC,SW-100,Histone deacetylases,Inhibitor,SW 100,inhibit,SW100
- 4-[(6-chloro-1,2,3,4-tetrahydroquinolin-1-yl)methyl]-N-hydroxybenzamide
- SW-100, 10 mM in DMSO
- 4-[(6-chloro-3,4-dihydro-2H-quinolin-1-yl)methyl]-N-hydroxybenzamide
- CAS:
- 2126744-35-0
- MF:
- C17H17ClN2O2
- MW:
- 316.78
- Mol File:
- 2126744-35-0.mol
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SW-100 Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- DMSO : ≥ 125 mg/mL (394.60 mM)
- form
- Solid
- color
- Light yellow to yellow
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SW-100 Usage And Synthesis
Uses
SW-100 HDAC6 Inhibitor is used in methods of treating PACS1 and PACS2 syndromes comprising administering an HDAC6 or SIRT2 inhibitor in relation to restoring Golgi morphology in a cell.
in vivo
SW-100 (20 mg/kg; i.p.; twice a day for two days) ameliorates several memory and learning impairments including novel object recognition, temporal ordering, and coordinate and categorical spatial processing in mouse model of Fragile X syndrome[1].
| Animal Model: | 8-10 weeks old C57BL/6 mice (Fmr1-/- mice)[1] |
| Dosage: | 20 mg/kg |
| Administration: | Intraperitoneal injection; twice a day for two days |
| Result: | Ameliorated several memory and learning impairments including novel object recognition, temporal ordering, and coordinate and categorical spatial processing in Fmr1-/- mice。 |
IC 50
HDAC1: 5.23 μM (IC50); HDAC2: 32.8 μM (IC50); HDAC3: 29.5 μM (IC50); HDAC4: 10.9 μM (IC50); HDAC5: 4.07 μM (IC50); HDAC6: 2.3 nM (IC50); HDAC7: 4.55 μM (IC50); HDAC8: 3.72 μM (IC50); HDAC9: 3.46 μM (IC50); HDAC10: 26.2 μM (IC50); HDAC11: 5.72 μM (IC50)
SW-100Supplier
Shanghai Lollane Biological Technology Co.,Ltd.
- Tel
- 021-52996696，15000506266 15000506266
Shanghai EFE Biological Technology Co., Ltd.
- Tel
- 021-65675885 18964387627
- info@efebio.com
Shanghai Chaolan Chemical Technology Center
- Tel
- 021-QQ：65489617 15618227136
- Sales@ATKchemical.com
Shanghai Han-Xiang Chemical Co., Ltd.
- Tel
- 15971444841
- amber@biochempartner.com
Fan De(Beijing) Biotechnology Co., Ltd.
- Tel
- 15911056312
- liming@bio-fount.com