9,15-DIOXO-11ALPHA-HYDROXY-2,3,4,5-TETRANOR-PROSTAN-1,20-DIOIC ACID CAS#: 24769-56-0

9,15-DIOXO-11ALPHA-HYDROXY-2,3,4,5-TETRANOR-PROSTAN-1,20-DIOIC ACID Basic information

Product Name:

9,15-DIOXO-11ALPHA-HYDROXY-2,3,4,5-TETRANOR-PROSTAN-1,20-DIOIC ACID

Synonyms:

11alpha-hydroxy-9,15-dioxo-2,3,4,5,20-pentanor-19-carboxyprostanoicacid
9,15-DIOXO-11ALPHA-HYDROXY-2,3,4,5-TETRANOR-PROSTAN-1,20-DIOIC ACID
TETRANOR PROSTAGLANDIN E METABOLITE
TETRANOR-PGEM
tetranor-PGEM Lipid Maps MS Standard
prostaglandin E2-UM
Cyclopentaneoctanoic acid, 2-(2-carboxyethyl)-5-hydroxy-ε,3-dioxo-, (1R,2R,5R)-
Tetranor-PGEM-13C6

CAS:

24769-56-0

MF:

C16H24O7

MW:

328.36

Product Categories:

Chiral Reagents
Intermediates & Fine Chemicals
Metabolites & Impurities
Pharmaceuticals

Mol File:

24769-56-0.mol

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9,15-DIOXO-11ALPHA-HYDROXY-2,3,4,5-TETRANOR-PROSTAN-1,20-DIOIC ACID Chemical Properties

Boiling point:: 622.2±50.0 °C(Predicted)
Density: 1.266±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: Not Stable; PBS (pH 7.2): 1 mg/ml
form: Liquid
pka: 4.61±0.10(Predicted)
color: Colorless to light yellow

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9,15-DIOXO-11ALPHA-HYDROXY-2,3,4,5-TETRANOR-PROSTAN-1,20-DIOIC ACID Usage And Synthesis

Description

tetranor-PGEM is the major urinary metabolite of PGE₁ and PGE₂, and is used as a marker of PGE₂ biosynthesis. About 15% of an infused dose of PGE₂ appears as this metabolite in the urine of humans. Normal healthy males excrete 7-40 μg of tetranor-PGEM over a 24-hour period.

Uses

The major urinary metabolite of Prostaglandin E2 (P838610).

Definition

ChEBI: A prostanoid that is prostaglandin E2 in which the acyclic hydroxy group has been oxidised to the corresponding ketone, the methyl group has been oxidised to the corresponding carboxylic acid and the 6-carboxyhexenyl group has been oxidatively cleaved to a 2-carboxyethyl group. It is the major urinary metabolite of prostaglandin E2.

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