Cav 2.2 blocker 1
Cav 2.2 blocker 1 Basic information
- Product Name:
- Cav 2.2 blocker 1
- Synonyms:
-
- Cav 2.2 blocker 1
- 1H-Pyrazole, 5-(4-chlorophenyl)-1-(2-methoxyphenyl)-3-(tetrahydro-2,2,6,6-tetramethyl-2H-pyran-4-yl)-
- Ca2+ channels,Inhibitor,inhibit,Cav 2.2 blocker 1,Ca channels,Calcium Channel
- 5-(4-Chlorophenyl)-1-(2-methoxyphenyl)-3-(2,2,6,6-tetramethyltetrahydro-2H-pyran-4-yl)-1H-pyrazole
- Cav 2.2 blocker 1, 10 mM in DMSO
- Cav 2.2 blocker 1 ，S0000
- CAS:
- 1567335-29-8
- MF:
- C25H29ClN2O2
- MW:
- 424.96
- Mol File:
- 1567335-29-8.mol
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Cav 2.2 blocker 1 Chemical Properties
- Boiling point:
- 547.2±50.0 °C(Predicted)
- Density
- 1.16±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 20.83 mg/mL (49.02 mM)
- pka
- -0.67±0.10(Predicted)
- form
- Solid
- color
- Off-white to light yellow
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Cav 2.2 blocker 1 Usage And Synthesis
Uses
Cav 2.2 blocker 1 (compound 9) is a N-type calcium channel (Cav 2.2) blocker for the treatment of pain, with an IC50 of 1 nM[1].
References
[1] Wall MJ, et al. Discovery and optimization of a novel series of pyrazolyltetrahydropyran N-type calcium channel (Cav 2.2) blockers for the treatment of pain. Bioorg Med Chem Lett. 2018 Dec 15;28(23-24):3780-3783. DOI:10.1016/j.bmcl.2018.10.007
Cav 2.2 blocker 1Supplier
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