N6-(P-AMINOBENZYL)ADENOSINE Chemical Properties

Boiling point:

749.0±70.0 °C(Predicted)

Density 

1.71±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

Soluble in DMSO

pka

13.12±0.70(Predicted)

form 

Solid

color 

Off-white to light yellow

N6-(P-AMINOBENZYL)ADENOSINE Usage And Synthesis

Uses

N-[(4-Aminophenyl)methyl]adenosine is a adenosine receptor inhibitor, with Ki of 29 nM for Rat ecto-5′-Nucleotidase. IC50 value: 29.0 ± 1.7 nM (Ki) Target: Adenosine Receptor

References

[1] Bhattarai S, et al. α,β-Methylene-ADP (AOPCP) Derivatives and Analogues: Development of Potent and Selective ecto-5'-Nucleotidase (CD73) Inhibitors. J Med Chem. 2015 Aug 13;58(15):6248-63. DOI:10.1021/acs.jmedchem.5b00802
[2] Chen JB, et al. Design and synthesis of novel dual-action compounds targeting the adenosine A(2A) receptor and adenosine transporter for neuroprotection. ChemMedChem. 2011 Aug 1;6(8):1390-400. DOI:10.1002/cmdc.201100126
[3] Zhu Z, et al. Constrained NBMPR analogue synthesis, pharmacophore mapping and 3D-QSAR modeling of equilibrative nucleoside transporter 1 (ENT1) inhibitory activity. Bioorg Med Chem. 2008 Apr 1;16(7):3848-65. DOI:10.1016/j.bmc.2008.01.044

N6-(P-AMINOBENZYL)ADENOSINE(95523-13-0)Related Product Information

• N6-(4-AMINOBENZYL)-N-METHYLCARBOXAMIDOADENOSINE
• N6-(P-AMINOBENZYL)ADENOSINE
• N6-BENZYLADENOSINE
• 6-Benzylaminopurine
• [125I]AB-MECA