RAC 8-HYDROXY EFAVIRENZ
RAC 8-HYDROXY EFAVIRENZ Basic information
- Product Name:
- RAC 8-HYDROXY EFAVIRENZ
- Synonyms:
-
- RAC 8-HYDROXY EFAVIRENZ
- 8-HydroxyEfavirenz
- 6-Chloro-4-(cyclopropyl-d4-ethynyl)-1,4-dihydro-8-hydroxy-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one
- (4S)-6-chloro-4-(2-cyclopropylethynyl)-8-hydroxy-4-(trifluoromethyl)-1H-3,1-benzoxazin-2-one
- Efavirenz Impurity 11(8-Hydroxy Efavirenz)
- 2H-3,1-Benzoxazin-2-one, 6-chloro-4-(2-cyclopropylethynyl)-1,4-dihydro-8-hydroxy-4-(trifluoromethyl)-, (4S)-
- 8-Hydroxy EfavirenzQ: What is 8-Hydroxy Efavirenz Q: What is the CAS Number of 8-Hydroxy Efavirenz Q: What is the storage condition of 8-Hydroxy Efavirenz Q: What are the applications of 8-Hydroxy Efavirenz
- 2H-3,1-Benzoxazin-2-one,6-chloro-4-(cyclopropylethynyl)-1,4-dihydro-8-hydroxy-4-(trifluoromethyl)-, (4S)-
- CAS:
- 205754-33-2
- MF:
- C14H9ClF3NO3
- MW:
- 331.67
- Product Categories:
-
- Intermediates & Fine Chemicals
- Isotope Labeled Compounds
- Metabolites
- Non-nucleoside Reverse Transcriptase
- Pharmaceuticals
- Mol File:
- 205754-33-2.mol
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RAC 8-HYDROXY EFAVIRENZ Chemical Properties
- Melting point:
- 144-154°C
- Boiling point:
- 373.6±42.0 °C(Predicted)
- Density
- 1?+-.0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Acetonitrile: soluble; DMSO: soluble; Methanol: soluble
- form
- A solid
- pka
- 7.18±0.40(Predicted)
- color
- White to off-white
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RAC 8-HYDROXY EFAVIRENZ Usage And Synthesis
Description
8-hydroxy Efavirenz is a major oxidative metabolite of the non-nucleoside reverse transcriptase inhibitor efavirenz . 8-hydroxy Efavirenz is formed when efavirenz is metabolized by the cytochrome P450 (CYP) isoform CYP2B6. It induces apoptosis in rat primary hippocampal neurons and loss of dendritic spines in rat primary hippocampal neuronal cultures when used at a concentration of 0.01 μM.
Chemical Properties
Off-White Solid
Uses
A labellebed metabolite of Efavirenz, a nonnucleoside HIV-1 reverse transcriptase inhibitor
Uses
8-Hydroxy Efavirenz is a metabolite of Efavirenz (E425000), a nonnucleoside HIV-1 reverse transcriptase inhibitor.
RAC 8-HYDROXY EFAVIRENZSupplier
Shanghai Devinchem Ltd Gold
- Tel
- 027-65318838 13646286950
- sales@devinchem.com
J & K SCIENTIFIC LTD.
- Tel
- 010-82848833 400-666-7788
- jkinfo@jkchemical.com
Chemsky (shanghai) International Co.,Ltd
- Tel
- 021-50135380
- shchemsky@sina.com
BOC Sciences
- Tel
- 16314854226
- info@bocsci.com
Shanghai EFE Biological Technology Co., Ltd.
- Tel
- 021-65675885 18964387627
- info@efebio.com
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RAC 8-HYDROXY EFAVIRENZ(205754-33-2)Related Product Information
- SE 563
- Efavirenz AMino Alcohol Ethyl CarbaMate
- rac Methyl Efavirenz
- Efavirenz Related Compound B (15 mg) ((S,E)-6-Chloro-4-(2-Cyclopropylvinyl)-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one)
- rac 8-Hydroxy Efavirenz
- Efavirenz Related Compound C (20 mg) (6-chloro-2-cyclopropyl-4-(trifluoromethyl)quinoline)
- 6-chloro-4-pent-1-ynyl-4-(trifluoromethyl)-1H-3,1-benzoxazin-2-one
- L 741211
- Efavirenz
- rac 8,14-Dihydroxy Efavirenz
- (S)-1-(2-Amino-5-chlorophenyl)-1-(trifluoromethyl)-3-cyclopropyl-2-propyn-1-ol
- (4S)-6-Chloro-4-(cyclopropylethynyl)-1,4-dihydro-2-(4-methoxyphenyl)-4-(trifluoromethyl)-2H-3,1-benzoxazine (Mixture of 2 Diastereomers)
- Efavirenz IP Impurity A
- rac 7-Hydroxy Efavirenz
- [4-Chloro-2-[(1S)-3-cyclopropyl-1-hydroxy-1-(trifluoromethyl)-2-propynyl)phenyl]carbamic Acid Methyl Ester
- (S)-5-chloro-a-(Cyclopropylacetenyl)-2-[((4-methoxyphenyl)methyl)amino]-a- (trifluoromethyl) benzenemethanol (E-4)
- Enantiomer Efavirenz
- Efavirenz Impurity 13(7-Hydroxy Efavirenz)