DIGITALIS (3 G)
DIGITALIS (3 G) Basic information
- Product Name:
- DIGITALIS (3 G)
- Synonyms:
-
- digitalone
- digitannoid
- digitol
- FOXGLOVE
- DIGITALISLANATA
- DIGITALIS (3 G)
- digitalin(pharmaceutical)
- digitalis,naturalproducts,pharmaceutical
- CAS:
- 8031-42-3
- MW:
- 0
- Mol File:
- Mol File
DIGITALIS (3 G) Chemical Properties
- EPA Substance Registry System
- Digitalis (8031-42-3)
DIGITALIS (3 G) Usage And Synthesis
Uses
Digitalis USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.
Biological Functions
Lanatoside A is composed of the aglycone digitoxigenin (genin indicates no sugar) connected to
three digitoxose sugar molecules, the third of which carries a 3-acetyl group, and a terminal glucose
molecule. In other words, the structure sequence is glucose4-3-acetyldigitoxose3-digitoxose2-
digitoxose1-digitoxigenin.
Lanatoside B has the identical sugar portion to lanatoside A, except that the aglycone has extra
hydroxyl group at C-16 and is given the name gitoxigenin. The structural sequence is glucose4-3-
acetyldigitoxose3-digitoxose2-digitoxose1-gitoxigenin.
Lanatoside C also has the same sugars found in both lanatosides A and B; however, the aglycone
has the nucleus of lanatoside A plus an additional hydroxyl group at C-12. This cardenolide is
named digoxigenin. The structural sequence is glucose4-3-acetyldigitoxose3-digitoxose2-digitoxose1-
digoxigenin.
Partial hydrolysis of the glucose molecule and the acetate group from lanatoside A and C produces,
respectively, two new and most important cardiac glycosides, digitoxin and digoxin, with the
following sequences: digitoxin, (digitoxose)3-digitoxigenin; and digoxin, (digitoxose)3-digoxigenin.