LAIR1 antibody Usage And Synthesis

Source

Rabbit

Reactivity

Human

Background

LAIR-1 is an inhibitory receptor that belongs to the Immunoglobulin superfamily. It has one extracellular Ig-like domain and an intracellular C-terminus with two ITIM domains. It is found on peripheral mononuclear cells, including NK, T, and B cells, and is thought to play a negative regulatory role on the cytolytic function of these cells through signaling through collagen ligation. LAIR1 has been noted to be upregulated in renal cell carcinoma, and may play a role in expansion of Th17 cell populations in collagen-rich environments, such as in graft rejection tissue.

References

[1] Meyaard, L. (2008) J Leukoc Biol 83, 799-803.
[2] Jingushi, K. et al. (2019) Oncol Rep 41, 1293-303.
[3] Agashe, V.V. et al. (2018) J Immunol 201, 772-81.

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