LYN antibody Usage And Synthesis

Source

Rabbit

Reactivity

Human;Mouse;Rat

Background

Lyn, one of the Src family members, is predominantly expressed in hematopoietic cells. Two tyrosine residues have been reported to play a crucial role in the regulation of protein tyrosine kinases of the Src family. Autophosphorylation of Tyr396, located in the catalytic domain, correlates with enzyme activation. Csk-mediated phosphorylation of the carboxy-terminal Tyr507 inactivates the kinase. Tyrosine phosphorylation and activation of Lyn occurs upon association with cell surface receptors such as the B cell Ag receptor and CD40. Studies using knockout mice have shown that the net effect of Lyn deficiency is to render B cells hypersensitive to BCR stimulation, suggesting that the most critical role for Lyn in vivo is in the down-regulation of B cell responses. Lyn is also involved in controlling the migration and development of specific B cell populations.

References

[1] Yamanashi, Y. et al. (1989) Proc. Natl. Acad. Sci. USA 86, 6538-6542.
[2] Yamanashi, Y. et al. (1991) Science 251, 192-194.
[3] Burkhardt, A.L. et al. (1991) Proc. Natl. Acad. Sci. USA 88, 7410-7414.
[4] Ren, C.L. et al. (1994) J. Exp. Med. 179, 673-680.
[5] Wang, J. et al. (1996) J Exp Med 184, 831-8.
[6] Chan, V.W. et al. (1997) Immunity 7, 69-81.
[7] Hibbs, M.L. et al. (1995) Cell 83, 301-11.
[8] Seo, S. et al. (2001) J Immunol 166, 3710-6.

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