RAB35 antibody Usage And Synthesis

Source

Rabbit

Reactivity

Human;Mouse;Rat

Background

Rab35 belongs to the small GTPase superfamily. By interacting with its specific GEF or GAP, Rab35 regulates cargo-specific endocytosis at the vesicle recycling step or mediates exocytosis at the exosome docking/tethering step. During cytokinesis, Rab35 interacts with OCRL phosphatase and is essential for maintaining intercellular bridge stability and abscission by controlling the concentration of phosphatidylinositol 4,5-bisphosphate and SEPT2 localization at the intercellular bridge. Rab35 also plays a role in actin assembly and the recruitment of Cdc42 and Rac1 to the site of filopodium by its direct interaction with actin-bundling protein fascin and actin-binding protein connecdenn 3.

References

[1] Patino-Lopez, G. et al. (2008) J Biol Chem 283, 18323-30.
[2] Sato, M. et al. (2008) EMBO J 27, 1183-96.
[3] Marat, A.L. and McPherson, P.S. (2010) J Biol Chem 285, 10627-37.
[4] Hsu, C. et al. (2010) J Cell Biol 189, 223-32.
[5] Kouranti, I. et al. (2006) Curr Biol 16, 1719-25.
[6] Dambournet, D. et al. (2011) Nat Cell Biol 13, 981-8.
[7] Zhang, J. et al. (2009) Science 325, 1250-4.
[8] Marat, A.L. et al. (2012) Mol Biol Cell 23, 163-75.
[9] Shim, J. et al. (2010) Mol Cell Biol 30, 1421-33.

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