2-HYDROXY-5-BENZYLOXYACETOPHENONE Chemical Properties

Melting point:

64-66°C

Boiling point:

391.2±27.0 °C(Predicted)

Density 

1.187±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,2-8°C

solubility 

Chloroform, Dichloromethane, Ethyl Acetate, Methanol

form 

Solid

pka

10.52±0.20(Predicted)

color 

Yellow

Safety Information

HS Code 

2914390090

2-HYDROXY-5-BENZYLOXYACETOPHENONE Usage And Synthesis

Chemical Properties

Yellow Solid

Uses

2-Hydroxy-5-benzyloxyacetophenone (cas# 30992-63-3) is a compound useful in organic synthesis.

Preparation

Preparation by reaction of benzyl chloride with quinacetophenone in refluxing acetone in the presence of potassium carbonate,
with potassium iodide (85%) ;
without potassium iodide (31%).

Synthesis

The second alternative method first employs benzyl groups to protect the hydroxyl functional group in 2,5-dihydroxyacetophenone, followed by an O-alkylation reaction under the same conditions to give acetophenone derivatives (1-6) in high yields (95%). Next, the acetophenone derivatives (1-6) were converted by the Vilsmeier-Haack reaction under standard conditions (70% yield) to the products (1-7) which were previously synthesized by other methods. Finally, the product (1-7) was subjected to Knoevenagel condensation reaction with diethyl malonate to give the target diester (1-8) in high yield (94%). Based on the analysis of the results of Scheme 2, it can be observed that both methods can be used for the synthesis of intermediates (1-7) from 2,5-dihydroxyacetophenone (1-4) in overall yields of 42% and 66%, respectively. However, the second method showed superior performance in terms of yield.

References

[1] Patent: WO2018/156459, 2018, A1. Location in patent: Page/Page column 22; 23
[2] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 1, p. 249 - 266
[3] Patent: US2007/88160, 2007, A1. Location in patent: Page/Page column 10-11
[4] Patent: US2010/22770, 2010, A1. Location in patent: Page/Page column 5-6
[5] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 4, p. 1410 - 1414